Surgery Today

, Volume 28, Issue 12, pp 1274–1278 | Cite as

Postoperative management following massive hepatectomy in a patient with Dubin-Johnson syndrome: Report of a case

  • Shinichi Ueno
  • Gen Tanabe
  • Kouichi Hanazono
  • Hiroki Ogawa
  • Shinro Yoshidome
  • Takashi Aikou
  • Aichi Yoshida
Case Reports


We report herein the case of a 46-year-old man with Dubin-Johnson syndrome (DJS) who was referred to our hospital to undergo a right hepatic lobectomy for hepatocellular carcinoma. His complicated postoperative conjugated hyperbilirubinemia was successfully treated by hemopurification based on the increased level of serum hepatocyte growth factor (HGF). It is considered that hemopurification based on the early postoperative HGF levels has beneficial effects for patients with DJS; however, the specific role of hemopurification in the conjugated hyperbilirubinemia that develops postoperatively in these patients has not been determined.

Key Words

Dubin-Johnson syndrome hepatocellular carcinoma hepatic lobectomy hepatocyte growth factor 


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Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  • Shinichi Ueno
    • 1
  • Gen Tanabe
    • 1
  • Kouichi Hanazono
    • 1
  • Hiroki Ogawa
    • 1
  • Shinro Yoshidome
    • 1
  • Takashi Aikou
    • 1
  • Aichi Yoshida
    • 2
  1. 1.First Department of SurgeryKagoshima University School of MedicineKagoshimaJapan
  2. 2.First Department of PathologyKagoshima University School of MedicineKagoshimaJapan

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