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Local cerebral blood flow measured by stable xenon CT during fentanyl-diazepam anesthesia

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Abstract

We assessed the local cerebral blood flow (LCBF) in 40 patients under fentanyl-diazepam anesthesia. The measurement of LCBF was made using 50%–70% stable xenon with 20 min of inhalation interval and a shuttle method for computed tomography imaging. All patients were anesthetized with 5.95±1.76 μg·kg−1 fentanyl and 0.22±0.07 mg·kg−1 diazepam under mechanical ventilation during CBF measurement. The values and distribution of LCBF on non-affected hemisphere appeared to be unaltered by fentanyldiazepam anesthesia. We also assessed the cerebral carbon dioxide reactivity in 6 patients. The cerebral carbon dioxide reactivity, expressed as percentage change in LCBF per unit change in arterial carbon dioxide partial pressure, was 5.39±1.07, and there were no significant differences of reactivity among regions studied. In conclusion, we showed reference values of LCBF and carbon dioxide reactivity, measured by stable xenon-enhanced computed tomography, in patients under fentanyl-diazepam anesthesia. Carbon dioxide reactivity was preserved in all regions including gray matter, white matter, and basal ganglia.

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Authors and Affiliations

  1. Department of Anesthesiology, National Cardiovascular Center, 5-7-1 Fujishirodai Suita, 565, Osaka, Japan

    Masahiko Kawaguchi, Masakazu Kuro, Hisatoshi Ohsumi & Toshito Nakajima

  2. Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai Suita, 565, Osaka, Japan

    Yoshihiro Kuriyama

  3. Department of Neurosurgery, Osaka Neurological Institute, 2-6-23 Shounai-Takaramachi, 561, Toyonaka, Osaka, Japan

    Jun Karasawa

Authors
  1. Masahiko Kawaguchi
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  2. Masakazu Kuro
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  3. Hisatoshi Ohsumi
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  4. Toshito Nakajima
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  5. Yoshihiro Kuriyama
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  6. Jun Karasawa
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Kawaguchi, M., Kuro, M., Ohsumi, H. et al. Local cerebral blood flow measured by stable xenon CT during fentanyl-diazepam anesthesia. J Anesth 8, 60–63 (1994). https://doi.org/10.1007/BF02482757

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  • DOI: https://doi.org/10.1007/BF02482757

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