Skip to main content
SpringerLink
Log in

Incidence, severity and time course of ROP in a randomized clinical trial of vitamin E prophylaxis

  • Published:
Documenta Ophthalmologica Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abbreviations

BW:

birth weight

E:

vitamin E

GA:

gestational age

NEC:

necrotizing enterocolitis

P:

placebo

PPRP:

pre-proliferative retinopathy

ROP:

retinopathy of prematurity

References

  1. Johnson L, Schaffer DB, Boggs TR. Vitamin E deficiency and retrolental fibroplasia. Am J Clin Nutr 1974; 27: 1158–73.

    PubMed  CAS  Google Scholar 

  2. Johnson L, Schaffer DB, Quinn GE, et al. Vitamin E supplementation and the retinopathy of prematurity. Ann NY Acad Sci 1982; 393: 473–95.

    PubMed  CAS  Google Scholar 

  3. Johnson L, Abbasi S, Quinn GE. Vitamin E and retinopathy of prematurity - Historical and clinical aspects. In CRC Handbook of Free Radicals and Antioxidants in Biomedicine. Ed.: Miguel J. CRC press, Boca Raton, 1989, Vol. II, pp 303–14.

    Google Scholar 

  4. Quinn GE, Schaffer DB, Johnson L. A revised classification of retinopathy of prematurity. Am J Ophthalmol 1982; 94: 744–9.

    PubMed  CAS  Google Scholar 

  5. Johnson L, Bowen FW, Abbasi A, et al. Relationship of prolonged pharmacologic serum levels of vitamin E to incidence of sepsis and necrotizing enterocolitis in infants with birth weight 1500 grams or less. Pediatr 1985; 75: 619–38.

    CAS  Google Scholar 

  6. Johnson L, Quinn GE, Abbasi E, et al. Effect of sustained pharmacologic vitamin E levels on incidence and severity of retinopathy of prematurity: A controlled clinical trial. J Pediatr 1989; 114: 827–38.

    Article  PubMed  CAS  Google Scholar 

  7. International committee for the classification of retinopathy of prematurity. An international classification of retinopathy of prematurity. Arch Ophthalmol 1984; 102: 1130–4.

    Google Scholar 

  8. Schaffer DB, Johnson L, Quinn GE, Weston M, Bowen FW. Vitamin E and retinopathy of prematurity: Follow-up at one year. Ophthalmol 1985; 92: 1005–22.

    CAS  Google Scholar 

  9. Schaffer DB, Johnson L, Quinn GE, Abbasi S, Otis C, Bowen FW. Vitamin E and retinopathy of prematurity: The ophthalmologist's perspective. March of Dimes Birth Defects: Original Article Series 1988; 24: 219–35.

    CAS  Google Scholar 

  10. Tasman W, Brown G, Schaffer D, Quinn G, Maidoff M, Benson W, Diamond G. Cryotherapy for active retinopathy of prematurity. Ophthalmol 1985; 93: 580–5.

    Google Scholar 

  11. Ehrenkranz RA. Vitamin E and retinopathy of prematurity: Still controversial. J Pediatr 1989; 114: 801–3.

    Article  PubMed  CAS  Google Scholar 

  12. Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicenter trial of cryotherapy for retinopathy of prematurity: Preliminary results. Arch Ophthalmol 1988; 106: 471–79.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, University of Pennsylvania School of Medicine, 19107, Philadelphia, PA, USA

    Lois Johnson, Chari Otis & Frank W. Bowen

  2. Department of Ophthalmology, University of Pennsylvania School of Medicine, 19107, Philadelphia, PA, USA

    Graham E. Quinn, Lois Johnson, Chari Otis, David B. Schaffer & Frank W. Bowen

Authors
  1. Graham E. Quinn
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lois Johnson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chari Otis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. David B. Schaffer
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Frank W. Bowen
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

The clinical trial was supported by the Retinal and Choroidal Diseases Branch of the National Eye Institute (Grant No. RO1EY01723).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Quinn, G.E., Johnson, L., Otis, C. et al. Incidence, severity and time course of ROP in a randomized clinical trial of vitamin E prophylaxis. Doc Ophthalmol 74, 223–228 (1990). https://doi.org/10.1007/BF02482612

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02482612

Key words

Search

Navigation