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Documenta Ophthalmologica

, Volume 74, Issue 3, pp 223–228 | Cite as

Incidence, severity and time course of ROP in a randomized clinical trial of vitamin E prophylaxis

  • Graham E. Quinn
  • Lois Johnson
  • Chari Otis
  • David B. Schaffer
  • Frank W. Bowen
Clinical and Epidemiological Aspects

Key words

retinopathy of prematurity premature infant time course vitamin E 

Abbreviations

BW

birth weight

E

vitamin E

GA

gestational age

NEC

necrotizing enterocolitis

P

placebo

PPRP

pre-proliferative retinopathy

ROP

retinopathy of prematurity

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References

  1. 1.
    Johnson L, Schaffer DB, Boggs TR. Vitamin E deficiency and retrolental fibroplasia. Am J Clin Nutr 1974; 27: 1158–73.PubMedGoogle Scholar
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    Johnson L, Schaffer DB, Quinn GE, et al. Vitamin E supplementation and the retinopathy of prematurity. Ann NY Acad Sci 1982; 393: 473–95.PubMedGoogle Scholar
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    Johnson L, Abbasi S, Quinn GE. Vitamin E and retinopathy of prematurity - Historical and clinical aspects. In CRC Handbook of Free Radicals and Antioxidants in Biomedicine. Ed.: Miguel J. CRC press, Boca Raton, 1989, Vol. II, pp 303–14.Google Scholar
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    Quinn GE, Schaffer DB, Johnson L. A revised classification of retinopathy of prematurity. Am J Ophthalmol 1982; 94: 744–9.PubMedGoogle Scholar
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    Johnson L, Bowen FW, Abbasi A, et al. Relationship of prolonged pharmacologic serum levels of vitamin E to incidence of sepsis and necrotizing enterocolitis in infants with birth weight 1500 grams or less. Pediatr 1985; 75: 619–38.Google Scholar
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    International committee for the classification of retinopathy of prematurity. An international classification of retinopathy of prematurity. Arch Ophthalmol 1984; 102: 1130–4.Google Scholar
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    Schaffer DB, Johnson L, Quinn GE, Weston M, Bowen FW. Vitamin E and retinopathy of prematurity: Follow-up at one year. Ophthalmol 1985; 92: 1005–22.Google Scholar
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    Schaffer DB, Johnson L, Quinn GE, Abbasi S, Otis C, Bowen FW. Vitamin E and retinopathy of prematurity: The ophthalmologist's perspective. March of Dimes Birth Defects: Original Article Series 1988; 24: 219–35.Google Scholar
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    Tasman W, Brown G, Schaffer D, Quinn G, Maidoff M, Benson W, Diamond G. Cryotherapy for active retinopathy of prematurity. Ophthalmol 1985; 93: 580–5.Google Scholar
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    Ehrenkranz RA. Vitamin E and retinopathy of prematurity: Still controversial. J Pediatr 1989; 114: 801–3.PubMedCrossRefGoogle Scholar
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    Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicenter trial of cryotherapy for retinopathy of prematurity: Preliminary results. Arch Ophthalmol 1988; 106: 471–79.Google Scholar

Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Graham E. Quinn
    • 2
  • Lois Johnson
    • 2
    • 1
  • Chari Otis
    • 2
    • 1
  • David B. Schaffer
    • 2
  • Frank W. Bowen
    • 2
    • 1
  1. 1.Department of PediatricsUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.Department of OphthalmologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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