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The mouse model of oxygen-induced retinopathy: A suitable animal model for angiogenesis research

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Abstract

Newborn mice exposed to high (>98%) ambient oxygen during the newborn period and subsequently removed to room air will develop a proliferative retinopathy which mimics the neovascular component of acute retinopathy of prematurity. In this paper, we report preliminary ultrastructural findings on the vitreous new vessels in the mouse model of oxygen-induced retinopathy, and argue that the model is appropriate for research on non surgical treatments for ROP in particular and angiogenesis in general.

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Abbreviations

ROP:

retinopathy of prematurity

mouse model:

the mouse model of oxygen-induced retinopathy (described in full in text)

HRP:

horseradish peroxidase

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Authors and Affiliations

  1. Department of Ophthalmology, The Flinders University of South Australia, 5042, Adelaide, SA, Australia

    Glen A. Gole, Jay Browning & Sonia M. Elts

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  1. Glen A. Gole
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  2. Jay Browning
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  3. Sonia M. Elts
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Gole, G.A., Browning, J. & Elts, S.M. The mouse model of oxygen-induced retinopathy: A suitable animal model for angiogenesis research. Doc Ophthalmol 74, 163–169 (1990). https://doi.org/10.1007/BF02482605

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  • DOI: https://doi.org/10.1007/BF02482605

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