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Iodine-131 human-mouse chimeric Fab monoclonal antibody A7 guided surgery for colorectal cancer patients: A pilot study

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Abstract

This study was conducted to determine the clinical usefulness of radioimmunoguided surgery (RIGS) using human-mouse chimeric Fab monoclonal antibody A7 (ch-Fab-A7) for colorectal cancer patients. Ten colorectal cancer patients were given iodine-131-labeled ch-Fab-A7 intravenously (i.v.) 2 to 7 days prior to RIGS. The RIGS was carried out using a portable gamma detecting probe (GDP). Tumor localization was identified by GDP intraoperatively in 4 of the ten patients, while liver metastasis and lymph node metastasis were identified in 2 patients and 1 patient, respectively. The GDP revealed tumor/surrounding tissue radio(γ)count ratios of 1.5 or greater in 8 of the ten resected tumors. Although RIGS using ch-Fab-A7 is a promising tool for intraoperatively identifying the tumor localization of colorectal cancer,125I, rather than131I, should be used as a tracer for RIGS to enhance the accuracy of ch-Fab-A7.

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Authors and Affiliations

  1. First Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kawaramachihirokoji, Kamigyo-ku, 602, Kyoto, Japan

    Kazuhito Yamamoto, Kazuya Kitamura, Satoki Nishida, Daisuke Ichikawa, Kazuma Okamoto, Toshiharu Yamaguchi & Toshio Takahashi

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  1. Kazuhito Yamamoto
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  2. Kazuya Kitamura
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  3. Satoki Nishida
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  4. Daisuke Ichikawa
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  5. Kazuma Okamoto
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  6. Toshiharu Yamaguchi
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  7. Toshio Takahashi
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Yamamoto, K., Kitamura, K., Nishida, S. et al. Iodine-131 human-mouse chimeric Fab monoclonal antibody A7 guided surgery for colorectal cancer patients: A pilot study. Surg Today 29, 190–193 (1999). https://doi.org/10.1007/BF02482249

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  • DOI: https://doi.org/10.1007/BF02482249

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