Abstract
Plasma cell myeloma (PCM) of the skull base is rarely encountered in neurosurgical practice. PCM has a wide spectrum of pathology, including a quite benign, solitary plasmacytoma (SPC), and an extremely malignant, multiple myeloma (MM) at the two ends of the spectrum. We have described two patients with PCM of the skull base, of which one harbored SPC, and the other progressed to MM. In case 1, a 46-year-old man presented with left multiple cranial nerve impairments and had a large skull base tumor. Subtotal removal was performed. The specimen and general examination, including bone marrow aspiration, revealed SPC. Postoperatively 50 Gy of external radiotherapy was administered. The patient has no manifestation of MM 24 months after the initial presentation. In case 2, a 53-year-old woman presented with left abducens palsy and had a left petroclival osteolytic mass. Gross total resection was performed. The specimen revealed a plasmablastic tumor, i.e., myeloma. General examination established the diagnosis of MM. She was administrated adjuvant chemotherapy and autologous bone marrow transplantation. She is alive without local recurrence 30 months after the initial presentation.
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References
Alexander MP, Goodkin DE, Poser CM (1975) Solitary plasmacytoma producing cranial neuropathy. Arch Neurol 32:777–778
Movsas TZ, Balcer LJ, Eggenberger ER (2000) Sixth nerve palsy as a presenting sign of intracranial plasmacytoma and multiple myeloma. J Neuroophthalmol 20:242–245
Nofsinger YC, Mirza N, Rowan PT (1997) Head and neck manifestations of plasma cell neoplasms. Laryngoscope 107:741–746
Arienta C, Caroli M, Ceretti L (1987) Solitary plasmacytoma of the calvarium: two cases treated by operation alone. Neurosurgery 21:560–563
Mancilla-Jimenez R, Tavassoli FA (1976) Solitary meningeal plasmacytoma: report of a case with electron microscopic and immunohistologic observations. Cancer 38:798–806
Krumholz A, Weiss HD, Jiji VH (1982) Solitary intracranial plasmacytoma: two patients with extended follow-up. Ann Neurol 11:529–532.
Du Preez JH, Branca EP (1991) Plasmacytoma of the skull: case reports. Neurosurgery 29:902–906
Marais J, Brookes GB, Lee C (1992) Solitary plasmacytoma of the skull base. Ann Otol Rhinol Laryngol 101:665–668
Rovit RL, Fager CA (1960) Solitary plasmacytoma of petrous bone: report of a case with neurological and radiographic remission following roentgen-ray therapy. J Neurosurg 17:929–933
Mancardi GL, Mandybur TI (1983) Solitary intracranial plasmacytoma. Cancer 51:2226–2233
Michaels L, Hyams VJ (1979) Amyloid in localized deposits and plasmacytomas of the respiratory tract. J Pathol 128:29–38
Miller FR, Lavertu P, Wanamaker JR (1998) Plasmacytoma of the head and neck. Otolaryngol Head Neck Surg 119:614–618
Cappell DF, Mathers RP (1935) Plasmacytoma of the petrous temporal bone and base of skull. J Laryngol Otol 50:340–349
Bindal AK, Bindal RK, Loveren H (1995) Management of intracranial plasmacytoma. J Neurosurg 83:218–221
Corwin J, Lindberg RD (1979) Solitary plasmacytoma of bone vs. extramedullary plasmacytoma and their relationship to multiple myeloma. Cancer 43:1007–1013
Schwartz TH, Rhiew R, Isaacson SR (2001) Association between intracranial plasmacytoma and multiple myeloma: clinicopathological outcome study. Neurosurgery 49:1039–1044
Vera CL, Kempe LG, Powers JM (1980) Plasmacytoma of the clivus presenting with an unusual combination of symptoms: case report. J Neurosurg 52:857–861
Toland J, Phelps PD (1971) Plasmacytoma of the skull base. Clin Radiol 22:93–96
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Higurashi, M., Yagishita, S., Fujitsu, K. et al. Plasma cell myeloma of the skull base: Report of two cases. Brain Tumor Pathol 21, 135–141 (2004). https://doi.org/10.1007/BF02482189
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DOI: https://doi.org/10.1007/BF02482189