Brain Tumor Pathology

, Volume 21, Issue 1, pp 47–52 | Cite as

Lipomatous meningioma of the brain harboring metastatic renal-cell carcinoma: A case report

  • Tomomi Kimiwada
  • Osamu Motohashi
  • Toshihiro Kumabe
  • Mika Watanabe
  • Teiji Tominaga
Case Report

Abstract

A 70-year-old woman presented with mild left hemiparesis and intermittent global headache. Magnetic resonance imaging showed a 6×6×6-cm tumor in the right frontal lobe, and abdominal computed tomography revealed a 8×8×7-cm mass lesion in the left kidney. Magnetic resonance imaging showed that the brain tumor consisted of a central hyperintense cystic component and an outer hypointense component. The patient underwent total surgical excision of the intracranial mass. Histological and immunohistochemical examination showed that the lesion was a lipomatous meningioma harboring metastatic renal-cell carcinoma. Both of these tumors are rare. The magnetic resonance imaging findings are indicative of but not specific to meningioma harboring metastatic tumor.

Key words

Lipomatous meningioma Renal-cell carcinoma Metastasis 

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References

  1. 1.
    Tally PW, Laws ER Jr, Scheithauer BW (1998) Metastases of central nervous system neoplasms: case report. J Neurosurg 68:811–816Google Scholar
  2. 2.
    Schmitt HP (1984) Metastasis of malignant neoplasms to intracranial tumours: the “tumour-in-a-tumour” phenomenon. Virchows Arch A Pathol Anat Histopathol 405:155–160PubMedCrossRefGoogle Scholar
  3. 3.
    Lodrini S, Savoiardo M (1981) Metastasis of carcinoma to intracranial meningioma. Report of two cases and review of the literature. Cancer 48:2668–2673PubMedCrossRefGoogle Scholar
  4. 4.
    Smith TW, Wang SY, Schoene WC (1981) Malignant carcinoid tumor metastatic to a meningioma. Cancer 47:1872–1877PubMedCrossRefGoogle Scholar
  5. 5.
    Honma K, Hara K, Sawai T (1989) Tumour-to-tumor metastasis: a report of two unusual autopsy cases. Virchows Arch A Pathol Anat Histopathol 416:153–157PubMedCrossRefGoogle Scholar
  6. 6.
    Wong A, Koszyca B, Blumbergs PC, et al. (1999) Malignant melanoma metastatic to a meningioma. Pathology 31:162–165PubMedCrossRefGoogle Scholar
  7. 7.
    Osterberg DH (1957) Metastases of carcinoma to meningioma. J Neurosurg 14:337–343PubMedGoogle Scholar
  8. 8.
    Watanabe T, Fujisawa H, Hasegawa M, et al (2002) Metastasis of breast cancer to intracranial meningioma. Case report. Am J Clin Oncol 25:414–417PubMedCrossRefGoogle Scholar
  9. 9.
    Bhargava P, McGrail KM, Mans HJ, et al (1999) Lung carcinoma presenting as metastasis to intracranial meningioma. Case report and review of literature. Am J Clin Oncol 22:199–202PubMedCrossRefGoogle Scholar
  10. 10.
    Stortbecker TP (1951) Metastatic hypernephroma of the brain from a neurosurgical point of view. J Neurosurg 8:185–197Google Scholar
  11. 11.
    Breadmore R, House R, Gonzales M (1994) Metastasis of renal cell carcinoma to a meningioma. Australas Radiol 38:141–143Google Scholar
  12. 12.
    Han HS, Kim EY, Han JY, et al (2000) Metastatic renal cell carcinoma in a meningioma: a case report. J Korean Med Sci 15:593–597PubMedGoogle Scholar
  13. 13.
    Roncaroli F, Scheithauer BW, Laeng RH, et al (2001) Lipomatous meningioma: a clinicopathologic study of 18 cases with special reference to the issue of metaplasia. Am J Surg Pathol 25:769–775PubMedCrossRefGoogle Scholar
  14. 14.
    Bailey P, Bucy PC (1931) The origin and nature of meningeal tumors. Am J Cancer 15:15–54Google Scholar
  15. 15.
    Kleihues P, Burger PC, Scheithauer BW (1993) The new WHO classification of brain tumors. Brain Pathol 3:255–268PubMedGoogle Scholar
  16. 16.
    Louis DN, Scheithauer BW, Budka H, et al (2000) Meningiomas In: Kleihues P, Canevee WK (eds) World Health Organization classification of tumours: tumours of the central nervous system. IARC, Lyon, pp 176–184Google Scholar
  17. 17.
    Chambers PW, Davis RL, Blanding JD, et al (1980) Metastases to primary intracranial meningiomas and neurilemomas. Arch Pathol Lab Med 104:350–354PubMedGoogle Scholar
  18. 18.
    Ogawa H, Iwaya K, Izumi M, et al (2002) Expression of CD 10 by stromal cells during colorectal tumor development. Hum Pathol 33:806–811PubMedCrossRefGoogle Scholar
  19. 19.
    Suzuki T, Ino K, Kikkawa F, et al (2002) Neutral endopeptidase/ CD10 expression during phorbol ester-induced differentiation of choriocarcinoma cells through the protein kinase C-and extracellular signal-regulated kinase-dependent signalling pathway. Placenta 23:475–482PubMedCrossRefGoogle Scholar
  20. 20.
    Kanitakis J, Bourchany D, Claudy A (2000) Expression of the CD10 antigen (neutral endopeptidase) by mesenchymal tumors of the skin. Anticancer Res 20:3539–3544PubMedGoogle Scholar
  21. 21.
    Kim MK, Kim S (2002) Immunohistochemical profile of common epithelial neoplasms arising in the kidney. Appl Immunohistochem Mol Morphol 10:332–338PubMedCrossRefGoogle Scholar
  22. 22.
    Yang B, Ali SZ, Rosenthal DL (2002) CD10 facilitates the diagnosis of metastatic renal cell carcinoma from primary adrenal cortical neoplasm in adrenal fine-needle aspiration. Diagn Cytopathol 27:149–152PubMedCrossRefGoogle Scholar
  23. 23.
    Chu P, Arber DA (2000) Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms. Frequent expression in renal cell carcinoma and endometrial stromal sarcoma. Am J Clin Pathol 113:374–382PubMedCrossRefGoogle Scholar
  24. 24.
    Avery AK, Beckstead J, Renshaw AA, et al (2000) Use of antibodies to RCC and CD10 in the differential diagnosis of renal neoplasms. Am J Surg Pathol 24:203–210PubMedCrossRefGoogle Scholar
  25. 25.
    Savoiardo M, Lodrini S (1980) Hypodense area within a meningioma: metastasis from breast cancer. Neuroradiology 20:107–110PubMedCrossRefGoogle Scholar
  26. 26.
    Rohringer M, Sutherland GR, Louw DF, et al (1989) Incidence and clinicopathologic features of meningioma. J Neurosurg 71:665–672PubMedCrossRefGoogle Scholar
  27. 27.
    Uchino A, Hasuo K, Mizushima A, et al (1996) Intracranial metastasis of renal cell carcinoma: MR imaging. Radiat Med 14:71–76PubMedGoogle Scholar
  28. 28.
    Kono K, Inoue Y, Nakayama K, et al (2001) The role of diffusion-weighted imaging in patients with brain tumors. AJNR Am J Neuroradiol 22:1081–1088PubMedGoogle Scholar
  29. 29.
    Filippi CG, Edgar MA, Ulug AM, et al (2001) Appearance of meningiomas on diffusion-weighted images: correlating diffusion constants with histopathologic findings. AJNR Am J Neuroradiol 22:65–72PubMedGoogle Scholar

Copyright information

© The Japan Society of Brain Tumor Pathology 2004

Authors and Affiliations

  • Tomomi Kimiwada
    • 1
  • Osamu Motohashi
    • 1
  • Toshihiro Kumabe
    • 1
  • Mika Watanabe
    • 2
  • Teiji Tominaga
    • 1
  1. 1.Department of NeurosurgeryTohoku University Graduate School of MedicineSendaiJapan
  2. 2.Department of PathologyTohoku University Graduate School of MedicineSendaiJapan

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