Abstract
Purpose
To develop a neurologic scoring (NS) system to objectively assess CNS function shortly after spinal cord ischemia.
Methods
Spinal cord ischemia was induced by temporarily clamping the infrarenal aorta in 27 rabbits anesthetized with isoflurane/N2O/O2 without muscle relaxants. Animals were divided ito group I, normothermic ischemia [I-a, 11 min (n=8); I-b, 12 min (n=8)], and group II, 60 min hypothermic ischemia targeted to II-a, 29.5°C (n=5), and II-i, 30.0°C (n=6). Postischemic neurologic function was scored from 0 to 6.
Results
Seventy-five percent of each group I subgroup ended with paraplegia. Function in the I-b group tended to be worse than in I-a (NS=1.7vs 1.9P>0.05). Hypothermia of 29.9±0.1°C protected partially (NS=2.8), whereas 29.4±0.1°C resulted in significantly higher NS, starting at 150 min (P<0.05vs IIi) with total recovery 5.5 hours (P<0.0001) post re-perfusion.
Conclusions
Protection of the spinal cord from ischemia can be objectively quantitated by our system. Protection strategies can be compared within 6 h of the ischemia-insult.
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References
Tarlov IM (1957) Spinal cord compression: mechanism of paralysis and treatment. Charles C Thomas, Springfield, IL, USA, p 147
Herold JA, Kron IL, Langenburg SE, Blackbourne LH, Tribble CG (1994) Complete prevention of postischemic spinal cord injury by means of regional infusion with hypothermic saline and adenosine. J Thorac Cardiovasc Surg 107:536–541
Ueno T, Furukawa K, Katayama Y, Suda H, Itoh T (1994) Spinal cord protection: development of a paraplegia-preventive solution. Ann Thorac Surg 58:116–120
Rokkas CK, Sundaresan S, Shuman TA, Palazzo RS, Nitta T, Despotis GJ (1993) Profound systemic hypothermia protects the spinal cord in a primate model of spinal cord ischemia. J Thorac Cardiovasc Surg 106:1024–1035
Miyamoto TA, Hosoi N, Chiba T, Shibata S, Saito H, Wakusawa R (1970) The effects of the “ideal pCO2” on the hemodynamics during surface induced hypothermia (in Japanese) Nihon Kyobu-Geka Gakkaishi (J Jpn Assoc Thorac Surg) 18:45–46
Michenfelder JD (1988) Anesthesia and the brain. Protecting the brain. Churchill Livingstone, New York, pp 181–193
Michenfelder JD (1988) Anesthesin and the Brain. Enflurane and isoflurane, Churchill Livingstone, New York. pp 79–91
Weiss J, Goldberg MP, Choi DW (1986) Ketamine protects cultured neocortical neurons from hypoxic injury. Brain Res 380:186–190
Michenfelder JD (1988) Anesthesia and the brain. Barbiturates. Churchill Livingstone, New York, pp 23–34
du Plessis AJ, Jonas RA, Wypij D, Hickey PR, Riviello J, Wessel DL, Roth SJ, Burrows FA, Walter G, Farrell DM, Walsh AZ, Plumb CA, del Nido P, Burke RP, Castañeda AR, Mayer JE, Newburger JW (1997) Perioperative effects of alpha-stat versus pH-stat strategies for deep hypothermic cardiopulmonary bypass in infants. J Thorac Candiovasc Surg 114:991–1001
Michenfelder JD (1988) Anesthesia and the brain. The hypothermic brain. Churchill Livingstone, New York, pp 23–34
Kirklin JW, Barrat-Boyes BG (1988) Hypothermia, circulatory arrest, and cardiopulmonary bypass. In: Cardiac Surgery. Churchill Livingstone, New York, pp 31–33
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Miyamoto, TA., Miyamoto, KJ. & Ohno, N. Objective assessment of CNS function within 6 hours of spinal cord ischemia in rabbits. J Anesth 12, 189–194 (1998). https://doi.org/10.1007/BF02481729
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DOI: https://doi.org/10.1007/BF02481729