Abstract
Chronic renal failure due to granulomatous interstitial nephritis in sarcoidosis is a rare phenomenon, and its response to corticosteroid therapy is not well known. We report a patient with sarcoidosis who presented with chronic renal failure and hypercalcemia, but who did not exhibit nephrocalcinosis. Renal histology findings showed the presence of noncaseating granuloma and heavy interstitial nephritis. Although hypercalcemia was remarkably improved by corticosteroid therapy, chronic renal failure, due to interstitial fibrosis and scarring, remained unchanged. This case reinforces evidence supporting the effectiveness of corticosteroid therapy in granulomatous interstitial nephritis of sarcoidosis, and suggests the need for early initiation of the therapy to avoid permanent renal dysfunction.
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Tamura, H., Okuda, H., Ida, T. et al. Chronic renal failure due to granulomatous interstitial nephritis in sarcoidosis: Response to corticosteroid therapy. Clin Exper Neph 2, 249–252 (1998). https://doi.org/10.1007/BF02480566
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DOI: https://doi.org/10.1007/BF02480566