Journal of Anesthesia

, Volume 12, Issue 3, pp 133–136 | Cite as

Effect of phenylephrine on histamine-induced bronchoconstriction in dogs

  • Kazuyoshi Hirota
  • Tetsumi Sato
  • Yoshio Hashimoto
  • Masatoshi Muraoka
  • Hironori Ishihara
  • Akitomo Matsuki
Original Articles



Although an α-adrenoceptor has been suggested to be involved in the mechanism of asthma, the effect of α1-agonist on the airway is still unclear. In this study we evaluated the effect of phenylephrine on the airway with a direct visualization method using a superfine fiberoptic bronchoscope (SFB).


Seven mongrel dogs were anesthetized with pentobarbital (30 mg·kg−1 IV) and paralyzed by pancuronium (0.2mg·kg−1·h−1). The trachea was intubated with an endotracheal tube (ID 7 mm) that has a second lumen for insertion of a SFB (OD 2.2 mm) to monitor the bronchial cross-sectional area (BCA) continuously. The tip of a SFB was placed at the level between the second and third bronchial bifurcation. To assess hemodynamics, the direct arterial blood pressure (ABP) and pulmonary arterial pressure (PAP) were monitored via a femoral arterial catheter and Swan-Granz catheter. Bronchoconstriction was elicited by histamine (10 μg·kg−1+ 500 μg·kg−1·h−1_. At 30 min after the histamine was started, saline or phenylephrine (1, 10, and 100μg·kg−1) was given intravenously. The BCA and hemodynamic variables were assessed before (basal) and 30 min after the histamine was started and 5 min after saline and each phenylephrine dose.


Histamine reduced BCA by 40.3±6.3%. Phenylephrine at 10 and 100 μg·kg−1 significantly increased the ABP and PAP; and it significantly decreased the BCA, by 6.5±6.9% and 14.2±7.9%, respectively. Plasma epinephrine and norepinephrine were also significantly reduced following phenylephrine 100 μg·kg−1 IV.


The dose of phenylephrine that produced vasopressive actions worsened the histamine-induced bronchoconstriction slightly but significantly. Therefore, phenylephrine should be used with caution in asthmatic patients.

Key words

α1-Agonist Phenylephrine Airway Broncho-constriction Bronchoscope Histamine 


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Copyright information

© JSA 1998

Authors and Affiliations

  • Kazuyoshi Hirota
    • 1
  • Tetsumi Sato
    • 1
  • Yoshio Hashimoto
    • 1
  • Masatoshi Muraoka
    • 1
  • Hironori Ishihara
    • 1
  • Akitomo Matsuki
    • 1
  1. 1.Department of AnesthesiologyUniversity of Hirosaki School of MedicineHirosakiJapan

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