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Journal of Anesthesia

, Volume 12, Issue 3, pp 133–136 | Cite as

Effect of phenylephrine on histamine-induced bronchoconstriction in dogs

  • Kazuyoshi Hirota
  • Tetsumi Sato
  • Yoshio Hashimoto
  • Masatoshi Muraoka
  • Hironori Ishihara
  • Akitomo Matsuki
Original Articles

Abstract

Purpose

Although an α-adrenoceptor has been suggested to be involved in the mechanism of asthma, the effect of α1-agonist on the airway is still unclear. In this study we evaluated the effect of phenylephrine on the airway with a direct visualization method using a superfine fiberoptic bronchoscope (SFB).

Methods

Seven mongrel dogs were anesthetized with pentobarbital (30 mg·kg−1 IV) and paralyzed by pancuronium (0.2mg·kg−1·h−1). The trachea was intubated with an endotracheal tube (ID 7 mm) that has a second lumen for insertion of a SFB (OD 2.2 mm) to monitor the bronchial cross-sectional area (BCA) continuously. The tip of a SFB was placed at the level between the second and third bronchial bifurcation. To assess hemodynamics, the direct arterial blood pressure (ABP) and pulmonary arterial pressure (PAP) were monitored via a femoral arterial catheter and Swan-Granz catheter. Bronchoconstriction was elicited by histamine (10 μg·kg−1+ 500 μg·kg−1·h−1_. At 30 min after the histamine was started, saline or phenylephrine (1, 10, and 100μg·kg−1) was given intravenously. The BCA and hemodynamic variables were assessed before (basal) and 30 min after the histamine was started and 5 min after saline and each phenylephrine dose.

Results

Histamine reduced BCA by 40.3±6.3%. Phenylephrine at 10 and 100 μg·kg−1 significantly increased the ABP and PAP; and it significantly decreased the BCA, by 6.5±6.9% and 14.2±7.9%, respectively. Plasma epinephrine and norepinephrine were also significantly reduced following phenylephrine 100 μg·kg−1 IV.

Conclusion

The dose of phenylephrine that produced vasopressive actions worsened the histamine-induced bronchoconstriction slightly but significantly. Therefore, phenylephrine should be used with caution in asthmatic patients.

Key words

α1-Agonist Phenylephrine Airway Broncho-constriction Bronchoscope Histamine 

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References

  1. 1.
    Barnes PJ, Basbaum CB, Nadel JA (1983) Autoradiographic localization of autonomic receptors in airway smooth muscle. Am Rev Respir Dis 127:758–762PubMedGoogle Scholar
  2. 2.
    Barnes PJ, Karliner JS, Dollery CT (1980) Human lung adrenoeceptors studied by radioligand binding. Clin Sci 58:457–461PubMedGoogle Scholar
  3. 3.
    Szentivanyi A (1968) Beta adrenergic theory of the atopic abnormality in bronchial asthma. J Allergy 42:203–232.CrossRefGoogle Scholar
  4. 4.
    Walden SM, Bleecker ER, Chahal K, Britt EJ Mason P, Permutt S (1984) Effect of alpha-adrenergic blockade on exercise-induced asthma and conditioned cold air. Am Rev Respir Dis 130:357–362PubMedGoogle Scholar
  5. 5.
    Barnes PJ, Wilson NM, Vickers H (1981) Prazocine, an alpha1-adrenoceptor antigonist, partially inhibits exercise-induced asthma. J Allergy Clin Immunol 68:411–415PubMedCrossRefGoogle Scholar
  6. 6.
    Moss J, Craigo PA (1994) The autonomic nervous system. In: Miller RD (ed) Anesthesia, 4th edn. Churchill Livingstone. New York, pp 523–576Google Scholar
  7. 7.
    Babe KS, Serafin WE (1996) Histamine, bradykinin and their antagonists. In: Hardman JG, Limbird LE (ed) Geodman & Gilman's the pharmacological basis of therapeutics, 9th edn. McGraw-Hill, New York, pp 581–600Google Scholar
  8. 8.
    Hashimoto Y, Hirota K, Ohtomo N, Ishihara H, Matsuki A (1996) In vivo direct measurement of the bronchodilating effect of sevoflurane using a superfine fibreoptic bronchoscope: comparison with enflurance and halothane. J Cardiothorac Vasc Anesth 10:213–216PubMedCrossRefGoogle Scholar
  9. 9.
    Otomo N, Hirota K, Sato T, Hashimoto Y, Ishihara H (1997) In vivo assessment of droperidol-induced bronchial relaxation in dogs using a superfine fibreoptic bronchoscope. Br J Anaesth 78:579–582PubMedGoogle Scholar
  10. 10.
    Otomo N, Hirota K, Hashimoto Y, Kushikata T, Sato T, Ishihara H, Matsuki A (1997) Measurement of bronchodilation using a superfine fibreoptic bronchoscope. Br J Anaesth 78:583–585PubMedGoogle Scholar
  11. 11.
    Hirota K, Ohtomo N, Hashimoto Y, Kudo T, Ishihara H, Matsuki A (1997) Midazolam reverses histamine-induced bronchoconstriction in dogs. Can J Anaesth 44:1115–1119PubMedCrossRefGoogle Scholar
  12. 12.
    Hirota K, Hashimoto Y, Sakai T, Sato T, Ishihara H, Matsuki A (1998) In vivo spasmolytic effect of ketamine and adrenaline on histamine-induced airway constriction: direct visualization method with a superfine fibreoptic bronchoscope. Acta Anaesthesiol Scand 42:184–188PubMedCrossRefGoogle Scholar
  13. 13.
    Kudo M, Kudo T, Oyama T (1984) The simultaneous determination of plasma concentration of norepinephrine, epinephrine and dopamine by gas chromatography-mass spectrometry. Masui 33:1099–1103.PubMedGoogle Scholar
  14. 14.
    Barnes PJ, Dollery CT, MacDermot (1980) Increased pulmonary α-adrenergic and reduced β-adrenergic receptors in experimental asthma. Nature 285:569–571PubMedCrossRefGoogle Scholar
  15. 15.
    Grandordy BM, Paiva DCJ, Regnard J, Florentin D, de Lauture D, Marsac J, Lockhart A (1995) The effect of intravenous phenylephrine on airway calibre in asthma. Eur Respir J 8:624–631PubMedGoogle Scholar
  16. 16.
    Scott JS, Garon H, Broadstone RV, Derksen FJ, Robinson NE (1988) Alpha1-adrenergic-induced airway obstruction in ponies with recurrent pulmonary disease. J Appl Physiol 65:687–692PubMedGoogle Scholar
  17. 17.
    Malo PE, Wasserman MA (1982) The modulation of adrenergic airway tone in normal and ascaris-sensitive beagle dogs. Eur J Pharmacol 86:27–34PubMedCrossRefGoogle Scholar
  18. 18.
    Brown RH, Herold CJ, Hirshman CA, Zerhouni EA, Mitzner W (1991) In vivo measurements of airway reactivity using high-resolution computed tomography. Am Rev Respir Dis 144:208–212PubMedGoogle Scholar
  19. 19.
    Brown RH, Mitzner W, Zerhouni E, Hirshman CA (1993) Direct in vivo visualization of bronchodilation induced by inhalational anesthesia using high-resolution computed tomography. Anesthesiology 78:295–300PubMedCrossRefGoogle Scholar
  20. 20.
    Leff AR, Munoz NM (1981) Evidence for two subtypes of alpha adrenergic receptors in canine airway smooth muscle. J Pharmacol Exp Ther 217:530–535PubMedGoogle Scholar
  21. 21.
    Gal TJ (1994) Bronchial hyperresponsiveness and anesthesia: physiologic and therapeutic perspectives. Anesth Analg 78:559–573.PubMedCrossRefGoogle Scholar
  22. 22.
    Larsson K (1985) Studies of sympatho-adrenal reactivity and adrenoceptor function in bronchial asthma. Eur J Respir Dis [Suppl] 141:1–52Google Scholar

Copyright information

© JSA 1998

Authors and Affiliations

  • Kazuyoshi Hirota
    • 1
  • Tetsumi Sato
    • 1
  • Yoshio Hashimoto
    • 1
  • Masatoshi Muraoka
    • 1
  • Hironori Ishihara
    • 1
  • Akitomo Matsuki
    • 1
  1. 1.Department of AnesthesiologyUniversity of Hirosaki School of MedicineHirosakiJapan

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