Journal of Anesthesia

, Volume 11, Issue 1, pp 38–43 | Cite as

Effects of bupivacaine and lidocaine on cardiac function in awake and pentobarbital-anesthetized rats

  • Satoshi Kashimoto
  • Marie-Françoise Doursout
  • Patrick Wouters
  • Takeshi Oguchi
Original Articles


Using an implanted Doppler crystal, we evaluated emodynamic changes induced by subconvulsive doses of bupivacaine and lidocaine in awake and pentobarbitalanesthetized rats. Low doses of lidocaine (2.0 mg·kg−1) and bupivacaine (0.5 mg·kg−1) changed hemodynamics minimally. However, a high dose of lidocaine (8.0 mg·kg−1) reduced heart rate, cardiac output, and regional myocardial wall thickening for a short period with or without anesthesia. In contrast, a high dose of bupivacaine (2.0 mg·kg−1) increased mean arterial pressure and did not change heart rate or regional myocardial wall thickening in the awake state. Under pentobarbital anesthesia, a high dose of lidocaine reduced mean arterial pressure significantly shortly after the injection, but bupivacaine did not. Thus, it is unlikely that bupivacaine has more potent cardiotoxicity than lidocaine in subconvulsive doses.

Key words

Local anesthetics Bupivacaine Lidocaine Heart Cardiac function 


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  1. 1.
    Albright GA (1979) Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. Anesthesiology 51:285–287PubMedGoogle Scholar
  2. 2.
    Nath S, Haggmark S, Johansson G, Reiz S (1986) Differential depressant and electrophysiologic cardiotoxicity of local anesthetics: An experimental study with special reference to lidocaine and bupivacaine. Anesth Analg 65:1263–1270PubMedCrossRefGoogle Scholar
  3. 3.
    Mets B, Janicki PK, James MF, Erskine R, Sasman B (1992) Lidocaine and bupivacaine cardiorespiratory toxicity is additive: A study in rats. Anesth Analg 75:611–614PubMedCrossRefGoogle Scholar
  4. 4.
    Fujita Y (1994) Comparative direct effects of lidocaine and bupivacaine on regional myocardial function in dogs at noncardiovascular toxic levels. Anesth Analg 78:1158–1163PubMedCrossRefGoogle Scholar
  5. 5.
    Komai H, Rusy BF (1981) Effects of bupivacaine and lidocaine on AV conduction in the isolated rat heart: Modification by hyperkalemia. Anesthesiology 55:281–285PubMedGoogle Scholar
  6. 6.
    Tanz RD, Heskett T, Loehning RW, Fairfax CA (1984) Comparative cardiotoxicity of bupivacaine and lidocaine in the isolated perfused mammalian heart. Anesth Analg 63:549–556PubMedGoogle Scholar
  7. 7.
    Clarkson CW, Hondeghem LM (1985) Mechanism for bupivancaine depression of cardiac conduction: Fast block of sodium channels during the action potential with slow recovery from block during diastole. Anesthesiology 62:396–405PubMedGoogle Scholar
  8. 8.
    Rosen MA, Thigpen JW, Shnider SM, Foutz SE, Levinson G, Koike M (1985) Bupivacaine-induced cardiotoxicity in hypoxic and acidotic sheep. Anesth Analg 64:1089–1096PubMedCrossRefGoogle Scholar
  9. 9.
    Lynch III C (1986) Depression of myocardial contractility in vitro by bupivacaine, etidocaine, and lidocaine. Anesth Analg 65:551–559PubMedGoogle Scholar
  10. 10.
    Kashimoto S, Doursout MF, Hartley C, Chelly JE (1993) Effects of thiopental and ketamine on cardiac function during moderate hemorrhage in chronically instrumented rats. J Cardiovasc Pharmacol 21:829–833PubMedGoogle Scholar
  11. 11.
    Chadwick HS (1985) Toxicity and resuscitation in lidocaine or bupivacaine-infused cats. Anesthesiology 63:385–390PubMedGoogle Scholar
  12. 12.
    Hartley CJ, Cole JS (1974) An ultrasonic pulsed Doppler system for measuring blood flow in small vessels. J Appl Physiol 37:626–629PubMedGoogle Scholar
  13. 13.
    Hartley CJ, Latson LA, Michael LH, Seidel CL, Lewis RM, Entman ML (1983) Doppler measurement of myocardial thickening with a single epicardial transducer. Am J Physiol 245:H1066–1072PubMedGoogle Scholar
  14. 14.
    Zhu WX, Myers ML, Hartley CJ, Roberts R, Bolli R (1986) Vandation of a single crystal for measurement of transmural and epicardial thickening. Am J Physiol 251:H1045–1055PubMedGoogle Scholar
  15. 15.
    Selvin BL (1987) Electroconvulsive therapy—1987. Anesthesiology 67:367–385PubMedGoogle Scholar
  16. 16.
    Blair MR (1975) Cardiovascular pharmacology of local anaesthetics. Br J Anaesth 47:247–252PubMedGoogle Scholar
  17. 17.
    Wheeler DM, Bradley EL, Woods WT (1988) The electrophysiologic actions of lidocaine and bupivacaine in the isolated, perfused canine heart. Anesthesiology 68:201–212PubMedGoogle Scholar
  18. 18.
    Nancarrow C, Rutten AJ, Runciman WB, Mather LE, Carapetis RJ, McLean CF, Hipkins SF (1989) Myocardial and cerebral drug concentrations and the mechanisms of death after fatal intravenous doses of lidocaine, bupivacaine, and ropivacaine in the sheep. Anesth Analg 69:276–283PubMedCrossRefGoogle Scholar
  19. 19.
    Moller RA, Convino BG (1988) Cardiac electrophysiologic effects of lidocaine and bupivacaine. Anesth Analg 67:107–114PubMedCrossRefGoogle Scholar
  20. 20.
    Kotelko DM, Shnider SM, Dailey PA, Brizgys RV, Levinson G, Shapiro WA, Koike M, Rosen MA (1984) Bupivacaine-induced cardiac arrhythmias in sheep. Anesthesiology 60:10–18PubMedGoogle Scholar
  21. 21.
    Heavner JE (1986) Cardiac dysrhythmias induced by infusion of local anesthetics into the lateral cerebral ventricle of cats. Anesth Analg 65:133–138PubMedGoogle Scholar
  22. 22.
    de La Coussaye JE, Bassoul B, Albat B, Peray PA, Gagnol JP, Eledjam JJ, Sassine A (1992) Experimental evidence in favor of the role of intracellular actions of bupivacaine in myocardial depression. Anesth Analg 74:698–702Google Scholar
  23. 23.
    Kasten GW, Martin ST (1986) Comparison of resuscitation of sheep and dogs after bupivacaine-induced cardiovascular collapse. Anesth Analg 65:1029–1032PubMedGoogle Scholar
  24. 24.
    de Jong RH, Bonin JD (1980) Deaths from local anesthetic-induced convulsions in mice. Anesth Analg 59:401–405PubMedGoogle Scholar
  25. 25.
    Cronau LH, Merin RG, Abouleish E, Steenberg M, Melgarejo AB (1988) Functional and metabolic effects of bupivacaine and lidocaine in the perfused working rat heart. Anesth Analg 67:929–935PubMedCrossRefGoogle Scholar
  26. 26.
    Liu PL, Feldman HS, Giasi R, Patterson MK, Covino BG (1983) Comparative CNS toxicity of lidocaine, etidocaine, bupivacaine, and tetracaine in awake dogs following rapid intravenous administration. Anesth Analg 62:375–359PubMedCrossRefGoogle Scholar
  27. 27.
    Thomas RD, Behbehani MM, Coyle DE, Denson DD (1986) Cardiovascular toxicity of local anesthetics: An alternative hypothesis. Anesth Analg 65:444–450PubMedCrossRefGoogle Scholar

Copyright information

© JSA 1997

Authors and Affiliations

  • Satoshi Kashimoto
    • 1
  • Marie-Françoise Doursout
    • 2
  • Patrick Wouters
    • 3
  • Takeshi Oguchi
    • 1
  1. 1.Department of AnesthesiologyYamanashi Medical UniversityYamanashiJapan
  2. 2.Department of AnesthesiologyUniversity of Texas Medical School at HoustonHoustonUSA
  3. 3.Department of Anesthesiology, Universitaire Ziekenhuizen GasthuisbergLeuven Catholic UniversityLeuvenBelgium

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