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Changes in peritoneal permeability due to chemical fibrosis

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Abstract

A relation between the mass transfer area coefficient (MTAC) and development of chemically induced fibrosis was evaluated. 20ml/kg of 0.08–0.2wt% chlorhexidine gluconate (CHG) was injected into the abdominal space of male Wistar rats (at 8 weeks). After 1–2h dwell, CHG was discarded and then the abdominal space was flushed with 20ml/kg of 0.9% saline solution three times. A peritoneal equilibration test (PET) was carried out every week for 1 month using Lactate Ringer solution containing 100 mg/dl of urea-N, 10 mg/dl of creatinine, and 1.5% of albumin. Eight out of 11 rats survived, 5 out of 8 rats developed adhesions, and 1 developed sclerosing encapsulating peritonitis-like degeneration. Although there was no statistically significant change in MTAC, MTAC increased from 1.18±0.66 ml/min to 1.92±0.6 ml/min in the first 3 weeks (P=0.09), and slightly decreased at the fourth week. It can be concluded that increase of MTAC may be due to increase of peritoneal permeability and/or increase of effective surface area such as angiogenesis.

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Authors and Affiliations

  1. Division of Applied Life Science, Graduate School of University of East Asia, 2-1 Ichinomiya-Gakuencho, 751-0807, Shimonoseki, Japan

    Kayo Hayashi MS & Takashi Horiuchi DEng

  2. Department of Mechanical Engineering, Toyo University, Kawagoe, Japan

    Yuji Ohta DEng

  3. Kidney Center, Kitasato University Hospital, Kitasato, Sagamihara, Japan

    Kazuo Kumano MD, PhD

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  1. Kayo Hayashi MS
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  2. Yuji Ohta DEng
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  3. Kazuo Kumano MD, PhD
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  4. Takashi Horiuchi DEng
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Correspondence to Takashi Horiuchi DEng.

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Hayashi, K., Ohta, Y., Kumano, K. et al. Changes in peritoneal permeability due to chemical fibrosis. J Artif Organs 1, 76–79 (1998). https://doi.org/10.1007/BF02479988

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  • DOI: https://doi.org/10.1007/BF02479988

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