Abstract
We investigated the vascular control status, including vasoactive hormones, systemic vascular resistance (SVR), and baroreceptor sensitivity, in prolonged nonpulsatile left heart bypass (NLHB). Nine goats underwent pulsatile left heart bypass (PLHB) with a ventricular assist device (VAD). Two weeks postoperatively, the VAD was replaced with a centrifugal pump and NLHB was subsequently conducted for 4 weeks. Thirteen healthy goats were also evaluated to obtain normal control data. The aortic pulse pressure on average was 37 mmHg for controls; 36mmHg at the end of PLHB; and 11, 9, 12, and 12mmHg at the end of the first, second, third, and fourth NLHB weeks, respectively. Plasma norepinephrine (NE), vaso-pressin (VP), renin activity (RA), and endothelin-I (ET) levels were measured for controls and at each point during PLHB and NLHB. The baseline SVR and the minimum SVR values after nitroglycerin injection were determined at each point during PLHB and NLHB. Baroreceptor sensitivity was calculated as the regression slope between R-R intervals and mean aortic pressure for controls and at each point during PLHB and NLHB. The plasma levels of NE, VP, RA, and EN did not change significantly during the entire course of the experiments. The baseline and minimum SVR values after nitroglycerin injection remained unchanged during PLHB and NLHB. Furthermore, the baroreceptor sensitivity did not change significantly during the entire course of the experiments. These results indicate that prolonged NLHB does not affect vascular control status, including the major vasoactive hormone levels, SVR, and baroreceptor sensitivity.
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References
Jarvik RK. System considerations favoring rotary artificial hearts with blood-immersed bearings. Artif Organs 1997;19:565–570
Wakisaka Y, Taenaka Y, Chikanari K, Nakatani T, Tatsumi E, Masuzawa T, Nishimura T, Takewa Y, Ohno T, Takano H. Long-term evaluation of a non-pulsatile mechanical circulatory support system. Artif Organs 1997;21:639–644
Yamada T, Nishimura K, Akamatsu T, Tsukiya T, Park CH, Kono S, Matsuda K, Ban T. In vivo testing of magnetically suspended centrifugal pump designed for long-term use. Int J Artif Organs 1997;20:562–569
Nishimura T, Tatsumi E, Takaichi S, Taenaka Y, Wakisaka Y, Nakatani T, Masuzawa T, Takewa Y, Nakamura M, Endo S, Nakata M, Takano H. Prolonged nonpulsatile left heart bypass with reduced systemic pulse pressure causes morphological changes in the aortic wall. Artif Organs 1998;22:405–410
Nishimura T, Tatsumi E, Takaichi S, Taenaka Y, Wakisaka Y, Nakatani T, Masuzawa T, Takewa Y, Nakamura M, Endo S, Sohn YS, Takano H. Morphological changes of the aortic wall due to reduced systemic pulse pressure in prolonged nonpulsatile left heart bypass. ASAIO J 1997;43:M691–695
Nishimura T, Tatsumi E, Takaichi S, Taenaka Y, Nishinaka T, Nakatani T, Masuzawa T, Nakata M, Nakamura M, Endo S, Takano H. Effects of long-term nonpulsatile left heart bypass on mechanical property of the aortic wall. ASAIO J 1999;45:455–459
Takano H, Nakatani T, Taenaka Y, Umezu M. Development of the ventricular assist pump system: experimental and clinical studies. In: Akutsu T, Koyanagi H (eds) Artificial heart 1. Tokyo: Springer-Verlag, 1986;141–150
Mancia G, Mark AL. Arterial baroreflexes in humans. In: Shepherd JT, Abboud FM (eds) Handbook of physiology, Section 2: The cardiovascular system. Vol III. Bethesda: American Physiological Society, 1983;755–793
Mary DASG, Hainsworth R. Methods for the study of cardiovascular reflexes. In: Hainsworth R, Mark AL (eds) Cardiovascular reflex control in health and disease. London: Saunders, 1993;1–34
Hickey PR, Buckley MJ, Philbin DM. Pulsatile and nonpulsatile cardiopulmonary bypass: review of a counterproductive controversy. Ann Thorac Surg 1983;36:720–737
Ninomiya I, Irisawa H. Aortic nervous activities in response to pulsatile and nonpulsatile pressure. Am J Physiol 1967;213:1504–1511
Angell-James JE. The effects of altering mean pressure, pulse pressure and pulse frequency of the impulse activity of baroreceptor fibers from the aortic arch and right subclavian artery in the rabbit. J Physiol (Lond) 1971;214:65–88
Angell-James JE, Daly M de B: Effects of graded pulsatile pressures on the reflex vasomotor responses elicited by changes of mean pressure in the perfused carotid sinus-aortic arch regions of dog. J Physiol (Lond) 1971;214:51–64
Valdes F, Jacobs GB, Murakami T, Harasaki H, Golding LR, Nose Y. Comparison of hemodynamic changes in a chronic nonpulsatile biventricular bypass (BVB) and total artificial heart (TAH). Trans Am Soc Artif Intern Organs 1980;26:455–460
Tatsumi E, Taenaka Y, Sakaki M, Nakatani T, Takano H. Rapid conversion of systemic flow pattern from pulsatile to non-pulsatile in conscious goats. In: Niimi H, Oda M, Sawada T, Xiu R-J (eds) Progress in microcirculation research. Oxford-New York-Tokyo: Pergamon, 1994;463–467
Skinner SL, McCubbin TW, Page IH. Control of renin secretion. Circ Res 1964;15:64–76
Trinkle JK, Helton NE, Bryant LR, Griffen WO. Pulsatile cardiopulmonary bypass: clinical evaluation. Surgery 197;68:1074–1078
Nakayama K, Tamiya T, Yamamoto K, Izumi T, Akimoto S, Hashizume S, Iimori T, Odaka M, Yazawa C. High amplitude pulsatile pump in extracorporeal circulation with particular reference to hemodynamics. Surgery 1963;54:798–809
Boucher JK, Rudy LW, Edmunds LH Jr. Organ blood flow during pulsatile cardiopulmonary bypass. J Appl Physiol 1974;36:86–97
Wesolowski SA, Sauvage LR, Pinc RD. Extracor. Extracorporeal circulation: the role of the pulse in maintenance of the systemic circulation during heart-lung bypass. Surgery 1955;37:663–682
Taenaka Y, Tatsumi E, Sakaki M, Sasaki E, Masuzawa T, Nakatoni T, Akagi H, Goto M, Matsuo Y, Inoue K, Baba Y, Kinoshita M, Takano H. Peripheral circulation during nonpulsatile systemic perfusion in chronic awake animals. Trans Am Soc Artif Intern Organs 1991;37:M365–366
Nishimura T, Tatsumi E, Nishinaka T, Taenaka Y, Nakata M, Takano H. Prolonged nonpulsatile left heart bypass diminishes vascular contractility. Int J Artif Organs 1999;22:492–498
Philbin DM, Levin FH, Kono K, Coggins CH, Moss J, Slater EE, Buckley M. Attenuation of the stress response to cardiopulmonary bypass by the addition of pulsatile flow. Circulation 1981;64:808–812
Landymore RW, Murphy DA, Kinley CE, Parrott JC, Moffitt EA, Longley WJ, Quibi AA. Does pulsatile flow influence the incidence of postoperative hypertension? Ann Thorac Surg 1979;28:261–268
Shoor PM, Marzec UM, Griffith LD, Hammill FS, Dilley RB, Bearnstein EF. Renin secretion in the chronically perfused pulseless calf: evidence for failure of stimulation by decreased pulse pressure. Circ Res 1979;45:100–107
Golding LR, Jacobs G, Murakami T, Takatani S, Yada I, Tomita K, Yozu R, Valdes F, Harasaki H, Fujimoto K, Nose Y. Chronic nonpulsatile blood flow. Trans Am Soc Artif Intern Organs 1982;28:81–85
Koushanpour E. Baroreceptor discharge behavior and resetting. In: Persson PB, Kirchheim HR (eds) Baroreceptor reflexes. Berlin, Heidelberg: Springer-Verlag, 1991;9–44
Chapleau MW, Abboud FM. Mechanisms of adaptation and resetting of the baroreceptor reflex. In: Hainsworth R, Mark AL (eds) Cardiovascular control in health and disease. London: WB Saunders, 1993;165–193
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Nishinaka, T., Koyanagi, H., Tatsumi, E. et al. Effect of prolonged nonpulsatile left heart bypass on vascular control status. J Artif Organs 3, 34–38 (2000). https://doi.org/10.1007/BF02479924
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DOI: https://doi.org/10.1007/BF02479924