Brain Tumor Pathology

, 18:151 | Cite as

Prognostic value of Ki-67 (MIB-1) and p53 in ependymomas

  • Sachio Suzuki
  • Hidehiro Oka
  • Nobuyuki Kawano
  • Satoshi Tanaka
  • Satoshi Utsuki
  • Kiyotaka Fujii
Original Article


To determine whether Ki-67 (MIB-1) and p53 have prognostic value in ependymomas, clinicopathologic study was undertaken in 29 patients with this tumor. The clinical course correlated well with the histological grade according to the World Health Organization (WHO) grading system, and it was the worst in patients with anaplastic ependymoma. The percent expression of MIB-1 and p53 correlated with the histological grade of malignancy. With regard to the subtypes of benign ependymoma, the clinical course was the worst in clear-cell ependymoma, which had a significantly higher expression of MIB-1 and p53 than the other subtypes. Tanycytic ependymoma showed the most benign clinical course and the lowest expression of MIB-1 and p53. Although the WHO grading generally tended to correlate with the clinical course of ependymomas, these two subtypes-clear-cell ependymoma and tanycytic ependymoma-exhibited biological properties different from those of other grade II ependymomas.

Key words

Ependymoma Subtype Histologic prognostic factors MIB-1 p53 


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Copyright information

© The Japan Society of Brain Tumor Pathology 2001

Authors and Affiliations

  • Sachio Suzuki
    • 1
  • Hidehiro Oka
    • 1
  • Nobuyuki Kawano
    • 2
  • Satoshi Tanaka
    • 1
  • Satoshi Utsuki
    • 1
  • Kiyotaka Fujii
    • 1
  1. 1.Department of NeurosurgeryKitasato University School of MedicineSagamihara, KanagawaJapan
  2. 2.Isobe ClinicSagamihara, KanagawaJapan

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