Abstract
Dysembryoplastic neuroepithelial tumor (DNT) is a relatively new nosologic entity. First described in 1988, it is now included in the “neuronal and mixed neuronal-glial tumours” category in the revised 2000 World Health Organization (WHO) Classification of Tumours of the Nervous System. The collective experience of more than 3000 reported cases indicates that, with only rare exceptions, DNTs are cerebral cortical lesions. At present, the actual incidence of extracortical DNT is unknown. We describe, the clinicopathologic features of the first tectal DNT. The patient was a 51-year-old man with a 2-month history of pulsatile headaches. On neurologic examination, the only abnormality was gait ataxia. Magnetic resonance imaging (MRI) demonstrated a midbrain tumor involving the tectum. It was hypointense on T1-weighted images and featured an iso-to hyperintense nodule at its center. The nodule showed enhancement upon contrast administration. No aqueductal obstruction or intraventricular extension of tumor was detected. The tumor was approached supratentorially and removed completely. The mucoid tumor was well demarcated from neural tissue. Histopathologically, it was a typical DNT, exhibiting a nodular pattern of growth with a “specific glioneuronal component”. This case report documents the first DNT to arise in the midbrain tectum and focuses on the problem of diagnosing this uncommon tumor at extracortical sites.
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Kleihues P, Burger PC, Scheithauer BW (1993) Histological typing of tumours of the central nervous system, 2nd edn. Springer, Berlin Heidelberg Vienna, p 23
Kleihues P, Cavenee WK (2000) Pathology and genetics of tumours of the nervous system. IARC Press, Lyon, pp 6–7
Cavanagh JB (1958) On certain small tumours encountered in the temporal lobe. Brain 81:389–405
Daumos-Duport C, Scheithauer BW, Chodkiewicz JP, et al (1988) Dysembryoplastic neuroepithelial tumor: a surgically curable tumor of young patients with intractable partial seizures. Report of thirty-nine cases. Neurosurgery 23:545–556
Daumos-Duport C (1993) Dysembryoplastic neuroepithelial tumours. Brain Pathol 3:283–295
Daumos-Duport C (1995) Patterns of tumor growth and problems associated with histological typing of low grade gliomas. In: Apuzzo MLJ (ed) Benign cerebral gliomas. AANS, Park Ridge, pp 125–147
Daumos-Duport C (1995) Dysembryoplastic neuroepithelial tumours in epilepsy surgery. In: Guerrini R (ed) Dysplasia of cerebral cortex and epilepsy. Raven, New York, pp 125–147
Honavar M, Ansari S, Janota I, et al (1991) Dysembryoplastic neuroepithelial tumor. Neuropathol Appl Neurobiol 17:242–243
Kirkpatrick PJ, Honavar M, Janota I, et al (1993) Control of temporal lobe epilepsy following en bloc resection of low grade tumors. J Neurosurg 78:19–25
Koeller KK, Dillon WP (1992) Dysembryoplastic neuroepithelial tumors: MR appearance. AJNR 13:1319–1325
Kuroiwa T, Bergey GK, Rothman MI, et al (1996) Radiologic appearance of the dysembryoplastic neuroepithelial tumor. Radiology 197:233–238
Prayson RA, Estes ML (1992) Dysembryoplastic neuroepithelial tumor. Am J Clin Pathol 97:398–401
Raymond AA, Halpin SF, Alsanjari N, et al (1994) Dysembryoplastic neuroepithelial tumor. Features in 16 patients. Brain 117:461–475
Taratuto AL, Pomata H, Sevlever G et al (1995) Dysembryoplastic neuroepithelial tumor: morphological, immunocytochemical, and deoxyribonucleic acid analyses in a pediatric series. Neurosurgery 36:474–481
Kuchelmeister K, Demirel T, Schlorer E, et al (1995) Dysembryoplastic neuroepithelial tumour of the cerebellum. Acta Neuropathol Berl 89:385–390
Yasha TC, Mohanty A, Radhesh S, et al (1998) Infratentorial dysembryoplastic neuroepithelial tumor (DNET) associated with Arnold-Chiari malformation. Clin Neuropathol 17:305–310
Fujimoto K, Ohnishi H, Tsujimoto M, et al (2000) Dysembryoplastic neuroepithelial tumor of the cerebellum and brainstem. J Neurosurg 93:487–489
Cervera-Pierot P, Varlet P, Chodkiewicz JP, et al (1997) Dysembryoplastic neuroepithelial tumours located in the caudate nucleus area: report of four cases. Neurosurgery 40:1065–1069
Leung SY, Gwi E, Ng HK, et al (1994) Dysembryoplastic neuroepithelial tumor. A tumor with small neuronal cells resembling oligodendroglioma. Am J Surg Pathol 18:604–614
Daumos-Duport C, Varlet Pascale, Bacha S, et al (1999) Dysembryoplastic neuroepithelial tumors. Nonspecific histological forms—a study of 40 cases. J Neurooncology 41:267–280
Komori T, Scheithauer BW, Anthony DC, et al (1998) Papillary glioneuronal tumor. A new variant of mixed neuronal-glial neoplasm. Am J Surg Pathol 22:1171–1183
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Kurtkaya-Yapicier, O., Elmaci, I., Boran, B. et al. Dysembryoplastic neuroepithelial tumor of the midbrain tectum: A case report. Brain Tumor Pathol 19, 97–100 (2002). https://doi.org/10.1007/BF02478934
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DOI: https://doi.org/10.1007/BF02478934