Skip to main content
SpringerLink
Log in

Gliosarcoma with angiosarcomatous features: A case report

  • Case Report
  • Published:
Brain Tumor Pathology Aims and scope Submit manuscript

Abstract

A surgical case of gliosarcoma in which the mesenchymal component showed angiosarcomatous features is reported. The neoplasm was extirpated from the right cerebral hemisphere of a 76-year-old man who presented with left hemiparesis and headache, and it was composed of both anaplastic astrocytomatous and sarcomatous elements. The sarcomatous element was composed of a proliferation of atypical endothelial cells that had pleomorphic, mitotically active nuclei and formed vascular lumina of irregular shapes or solid cellular sheets, and was accompanied by the deposition of collagenous matrix. The cytoplasm of some of the atypical endothelial cells was immunohistochemically positive for vimentin, factor VIII-related antigen, CD 34, and thrombomodulin. The MIB-1 labeling index of the sarcomatous component was higher than that of the astrocytomatous component.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Feigin JH, Gross SW (1955) Sarcoma arising in glioblastoma of the brain. Am J Pathol 31:633–653

    PubMed  CAS  Google Scholar 

  2. Rubinstein LJ (1964) Morphological problems of brain tumors with mixed cell population. Acta Neurochir (Suppl) 10:141–165

    Google Scholar 

  3. Morantz RA, Feigin I, Ransohoff J (1976) Clinical and pathological study of 24 cases of gliosarcoma. J Neurosurg 45:398–408

    PubMed  CAS  Google Scholar 

  4. Slowik F, Jellinger K, Gas zó L, et al. (1985) Gliosarcomas. Histological, immunohistochemical, ultrastructural, and tissue culture studies. Acta Neuropathol 67:201–210

    Article  PubMed  CAS  Google Scholar 

  5. Meis JM, Martz KL, Nelson JS (1991) Mixed glioblastoma multiforme and sarcoma. A clinicopathologic study of 26 radiation therapy oncology group cases. Cancer 67:2342–2349

    Article  PubMed  CAS  Google Scholar 

  6. Russell DS, Rubinstein LJ (1989) Pathology of tumours of the nervous system, 5th edn, Edward Arnold, London

    Google Scholar 

  7. Lantos PL, VandenBerg SR, Kleihues P (1997) Tumours of the nervous system. In: Graham DI, Lantos PL (eds) Greenfield's neuropathology, 6th edn. Edward Arnold, London, pp 583–879

    Google Scholar 

  8. Feigin I, Allen LB, Lipkin L, et al. (1958) The endothelial hyperplasia of the cerebral blood vessels with brain tumors, and its sarcomatous transformation. Cancer 11:264–277

    Article  PubMed  CAS  Google Scholar 

  9. Friede RL (1978) Gliofibroma. A peculiar neoplasia of collagen forming glia-like cells. J Neuropathol Exp Neurol 37:300–313

    PubMed  CAS  Google Scholar 

  10. Ng HK, Poon WS (1990) Gliosarcoma of the posterior fossa with features of a malignant fibrous histiocytoma. Cancer 65:1161–1166

    Article  PubMed  CAS  Google Scholar 

  11. Goldman RL (1969) Gliomyosarcoma of the cerebrum. Report of a unique case. Am J Clin Pathol 52:741–744

    PubMed  CAS  Google Scholar 

  12. Barnard RO, Bradford R, Scott T, et al. (1986) Gliomyosarcoma. Report of a case of rhabdomyosarcoma arising in a malignan glioma. Acta Neuropathol 69:23–27

    Article  PubMed  CAS  Google Scholar 

  13. Richman AV, Balis GA, Maniscalco JE (1980) Primary intracerebral tumor with mixed chondrosarcoma and glioblastoma— gliosarcoma or sarcoglioma? J Neuropathol Exp Neurol 39:329–335

    Article  PubMed  CAS  Google Scholar 

  14. Banerjee AK, Sharma BS, Kak VK, et al. (1989) Gliosarcoma with cartilage formation. Cancer 63:518–523

    Article  PubMed  CAS  Google Scholar 

  15. Hayashi K, Ohara N, Jeon HJ, et al. (1993) Gliosarcoma with features of chondroblastic osteosarcoma. Cancer 72:850–855

    Article  PubMed  CAS  Google Scholar 

  16. Pasquier B, Coudere P, Pasquier D, et al. (1978) Sarcoma arising in oligodendroglioma of the brain. A case with intramedullary and subarachnoid spinal metastases. Cancer 42:2753–2758

    Article  PubMed  CAS  Google Scholar 

  17. Louis DN, Hedley-Whyte ET, Martuza RL (1989) Sarcomatous proliferation of the vasculature in a subependymoma. Acta Neuropathol 78:332–335

    Article  PubMed  CAS  Google Scholar 

  18. McComb RD, Jones TR, Pizzo SV, et al. (1982) Immunohistochemical detection of factor VIII/von Willebrand factor in hyperplastic endothelial cells in glioblastoma multiforme and mixed glioma-sarcoma. J Neuropathol Exp Neurol 41:479–489

    PubMed  CAS  Google Scholar 

  19. Kishikawa M, Tsuda N, Fujii H, et al. (1986) Glioblastoma with sarcomatous component associated with myxoid change. A histochemical, immunohistochemical and electron microscopic study. Acta Neuropathol 70:44–52

    Article  PubMed  CAS  Google Scholar 

  20. Haddad SF, Moore SA, Schelper RL, et al. (1992) Smooth muscle can comprise the sarcomatous component of gliosarcomas. J Neuropathol Exp Neurol 51:493–498

    PubMed  CAS  Google Scholar 

  21. Kochi N, Budka H (1987) Contribution of histiocytic cells to sarcomatous development of the gliosarcoma. An immunohistochemical study. Acta Neuropathol 73:124–130

    Article  PubMed  CAS  Google Scholar 

  22. Schiffer D, Giordana MT, Mauro A, et al. (1984) GFAP, F VIII/RAg, laminin, and fibronectin in gliosarcomas. An immunohistochemical study. Acta Neuropathol 63:108–116

    Article  PubMed  CAS  Google Scholar 

  23. Kepes JJ, Bastian FO, Weber ED (1996) Gliosarcoma developing from an irradiated ependymoma. Acta Neuropathol 92:515–519

    Article  PubMed  CAS  Google Scholar 

  24. Greene HSN, Harvey EK (1968) The development of sarcomas from transplants of the hyperplastic stromal endothelium of glioblastoma multiforme. Am J Pathol 53:483–499

    Google Scholar 

  25. Albrecht S, Connelly JH, Bruner JM (1993) Distribution of p53 protein expression in gliosarcomas. An immunohistochemical study. Acta Neuropathol 85:222–226

    PubMed  CAS  Google Scholar 

  26. Paulus W, Bayas A, Ott G, et al. (1994) Interphase cytogenetics of glioblastoma and gliosarcoma. Acta Neuropathol 88:420–425

    PubMed  CAS  Google Scholar 

  27. Biernat W, Aguzzi A, Sure U, et al. (1995) Identical mutations of the p53 tumor suppressor gene in the gliomatous and the sarcomatous components of gliosarcomas suggest a common origin from glial cells. J Neuropathol Exp Neurol 54:651–656

    PubMed  CAS  Google Scholar 

  28. Boerman RH, Anderl K, Herath J, et al. (1996) The glial and mesenchymal elements of gliosarcomas share similar genetic alterations. J Neuropathol Exp Neurol 55:973–981

    PubMed  CAS  Google Scholar 

  29. Bozóky B, Kemény F, Krenács T, et al. (1991) Gliosarcomas as a result of a sarcomatous differentiation of glial tumor cells. Brain Tumor Pathol 8:45–49

    Google Scholar 

  30. Jones H, Steart PV, Weller RO (1991) Spindle-cell glioblastoma or gliosarcoma? Neuropathol Appl Neurobiol 17:177–187

    PubMed  CAS  Google Scholar 

  31. Wesseling P, Vandersteenhoven JJ, Downey BT, et al. (1993) Cellular components of microvascular proliferation in human glial and metastatic brain neoplasms. A light microscopic and immunohistochemical study of formalin-fixed, routinely processed material. Acta Neuropathol 85:508–514

    Article  PubMed  CAS  Google Scholar 

  32. Nagashima T, Hoshino T, Cho KG (1987) Proliferative potential of vascular components in human glioblastoma multiforme. Acta Neuropathol 73:301–305

    Article  PubMed  CAS  Google Scholar 

  33. Lalitha VS, Rubinstein LJ (1979) Reactive glioma in intracranial sarcoma. A form of mixed sarcoma and glioma (“sarcoglioma”). Report of eight cases. Cancer 43:246–257

    Article  PubMed  CAS  Google Scholar 

  34. Charman HP, Lowenstein DH, Cho KG, et al. (1988) Primary cerebral angiosarcoma. Case report. J Neurosurg 68:806–810

    Article  PubMed  CAS  Google Scholar 

  35. Mena H, Ribas JL, Enzinger FM, et al. (1991) Primary angiosarcoma of the central nervous system. Study of eight cases and review of the literature. J Neurosurg 75:73–76

    Article  PubMed  CAS  Google Scholar 

  36. Bonnin JM, Peña CE, Rubinstein LJ (1983) Mixed capillary hemangioblastoma and glioma. A redefinition of the “angioglioma.”, J Neuropathol Exp Neurol 42:504–516

    PubMed  CAS  Google Scholar 

  37. Lombardi D, Scheithauer BW, Piepgras D, et al. (1991) “Angioglioma” and the arteriovenous malformation-glioma association J Neurosurg 75:589–596

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Osaka Red Cross Hospital, 5-53 Fudegasaki, Tennoji, 543-8555, Osaka, Japan

    Masayuki Shintaku

  2. Department of Neurosurgery, Kyoritsu Hospital, Kawanishi

    Katsuya Miyaji

  3. First Department of Pathology, Kansai Medical University, Moriguchi

    Yasushi Adachi

Authors
  1. Masayuki Shintaku
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Katsuya Miyaji
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yasushi Adachi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shintaku, M., Miyaji, K. & Adachi, Y. Gliosarcoma with angiosarcomatous features: A case report. Brain Tumor Pathol 15, 101–105 (1998). https://doi.org/10.1007/BF02478891

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02478891

Key words

Search

Navigation