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Sinus histiocytosis with massive lymphadenopathy: A case of multiple dural involvement

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Abstract

An exeptional case of Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) arising from the meninges in a 60-year-old Japanese man is presented. Computerized tomographic scans and magnetic resonance images demonstrated well-circumscirbed tumorous lesions that were homogeneously enhanced with contrast medium. Systemic examination revealed no abnormalities except for a cervical lymphadenopathy and diabetes mellitus. Microscopic examination of the resected specimens showed proliferated histiocytosis and infiltration of plasma cells and lymphocytes. The histology was characterized by the presence of histiocytes demonstrating lymphophagocytosis and immunoreactivity for S-100 protein staining. Immunohistochemical studies and electron microscopy were useful in confirming the diagnosis. The clinical and histopathological features of this disease are discussed.

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Author notes

  1. Keiichi Sakai

    Present address: Department of Neurosurgery, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan

Authors and Affiliations

  1. Department of Neurological Surgery, Aichi Medical University, Aichi, Japan

    George Koike

  2. Department of Neurosurgery, Seguchi Neurosurgical Hospital, Iida, Japan

    Kyoji Seguchi

  3. First Department of Pathology, Gumma University School of Medicine, Maebashi, Japan

    Yoichi Nakazato

Authors
  1. Keiichi Sakai
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  2. George Koike
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  3. Kyoji Seguchi
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  4. Yoichi Nakazato
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Corresponding author

Correspondence to Keiichi Sakai.

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Sakai, K., Koike, G., Seguchi, K. et al. Sinus histiocytosis with massive lymphadenopathy: A case of multiple dural involvement. Brain Tumor Pathol 15, 63–69 (1998). https://doi.org/10.1007/BF02478885

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  • DOI: https://doi.org/10.1007/BF02478885

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