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The bulletin of mathematical biophysics

, Volume 8, Issue 4, pp 129–133 | Cite as

The half-life of a drug in relation to its therapeutic index

  • H. D. Landahl
Article
  • 65 Downloads

Abstract

A procedure is given for the determination of the effective half-life of a drugin vivo with respect to an arbitrary response. If the half-life of the drug with respect to toxicity is different from that for therapy, the therapeutic index would be expected to depend on the temporal spacing of the dose. Equations are derived for this variation for a special case.

Keywords

Effective Dose Therapeutic Index Biophysics Volume Theoretical Curf Temporal Spacing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The University of Chicago Press 1946

Authors and Affiliations

  • H. D. Landahl
    • 1
  1. 1.The University of Chicago Toxicity Laboratory and Section of Mathematical BiophysicsChicagoUSA

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