The bulletin of mathematical biophysics

, Volume 6, Issue 4, pp 133–139 | Cite as

On the theory of blood-tissue exchanges: II. Applications

  • R. E. Smith
  • M. F. Morales


The application of a previously developed theory of inert gas absorption is here outlined. Interpretation of uptake curves and the method of obtaining tissue constants from such curves is discussed, together with illustrations from actual experiment. A critique of previous analytic procedures is included.


Saponin Ethyl Ether Terminal Portion Uptake Curve Elimination Constant 
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  1. Behnke, A. al 1935. “The Rate of Elimination of Dissolved Nitrogen in Man in Relation to Fat and Water Content.”Am. Jour. Physiol.,114, 137–148.Google Scholar
  2. Haggard, H. W. 1924. “The Absorptions, Distribution and Elimination of Ethyl Ether: II. Analysis of the Mechanism of Absorption and Elimination of Such a Gas or Vapor as Ethyl Ether.”J. Biol. Chem.,59, 753–761.Google Scholar
  3. Müller, F. H. 1941. “The Diffusion of Gases Through Highly Polymerized Materials: A Simple Apparatus for the Measuring of the Diffusion of Gases Through Foils.”Physik. Zeit.,42, 48–53.Google Scholar
  4. Smith, R. E., and Morales, M. F. 1944. “On the Theory of Blood-Tissue Exchanges: I. Fundamental Equations.”Bull. Math. Biophysics,6, 125–131.CrossRefGoogle Scholar

Copyright information

© The University of Chicago Press 1944

Authors and Affiliations

  • R. E. Smith
    • 1
  • M. F. Morales
    • 1
  1. 1.Naval Medical Research InstituteNational Naval Medical CenterBethesda

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