The bulletin of mathematical biophysics

, Volume 25, Issue 2, pp 125–139 | Cite as

On visual adaptation: II. The electroretinogram and the bipolar cells

  • Harold White


First a model for theb-wave of the electroretinogram is given. The essential part of the model is the diffusion into the rod-bipolar synapse of a transmitter substance, followed by the induction of an inhibitor. Making use of this model, adaptation to an illumination too weak to cause of significant decrease in the concentration of visual pigment is interpreted as due to a decreased effectiveness of the rod impulse in exciting the bipolar cell. The disparity between threshold changes for very small test spots and for relatively large spots is explained simply, without invoking any additional physiological mechanisms.


Bipolar Cell Visual Pigment Test Spot Threshold Change Spatial Summation 
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Copyright information

© University of Chicago 1963

Authors and Affiliations

  • Harold White
    • 1
  1. 1.Committee on Mathematical BiologyThe University of ChicagoChicagoUSA

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