Abstract
Mathematical models are presented for the relationship between changes in the bar pressing rate of albino rats on a continuous reinforcement schedule and alterations of the brain amines norepinephrine and serotonin induced by electrolytic lesions in the hypothalamus and by the drug, reserpine. The discussion utilizes central concepts from some of the more prominent hypotheses on the relation of the amines to behavior and for the potentiation effects of the drug by the lesion (A. Carlsson, 1964. “Functional Significance of Drug-induced Changes in Brain Monoamine Levels.” InBiogenic Amines, eds. H. E. Himwich and W. A. Himwich, New York: Elsevier, 9–27; B. B. Brodie and E. Costa, 1962. “Some Current Views on Brain Monoamines.”Psychopharm. Service Centre Bull.,2, 1–25.) Laboratory data (F. Grabarits and J. Harvey, 1966. “The Effects of Reserpine on Behavior and on Brain Concentrations of Serotonin and Norepinephrine in Control Rats and Rats with Hypothalamic Lesions.”J. Pharm.,153, 403–411) are interpreted, and suggestions for further experimental and theoretical work are made.
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Literature
Brodie, B. B. and E. Costa. 1962. “Some Current Views on Brain Monoamines.”Psychopharm. Service Center Bull.,2, 1–25.
Cannon, W. B. and A. Rosenblueth. 1949.The Supersensitivity of Denervated Structures: A Law of Denervation. New York: Macmillan Company.
Carlsson, A. 1964. “Functional Significance of Drug-induced Changes In Brain Monoamine Levels,” inBiogenic Amines, eds., H. E. Himwich and W. A. Himwich. New York: Elsevier. 9–27.
Carlton, P. L. 1963. “Cholinergic Mechanisms in the Control of Behavior by the Brain.”Psychological Review,70, 19–40.
Cox, D. R. and W. L. Smith. 1962.Queues, Chap. 2, London: Methuen or New York: John Wiley.
Grabarits, F. 1965.A Biochemical Investigation of Increased Sensitivity to Reserpine in Rats with Bilateral Lesions in the Medial Forebrain Bundle. Ph.D. dissertation. University of Chicago.
Grabarits, F. and J. A. Harvey. 1966. “The Effects of Reserpine on Behavior and on Brain Concentrations of Serotonin and Norepinephrine in Control Rats and Rats with Hypothalamic Lesions.”J. of Pharm.,153, 401–411.
Harvey, J. A. 1965. “Comparison Between the Effects of Hypothalamic Lesions on Brain Amine Levels and Drug Action.” —Ibid.,144, 24–36.
Heller, A., J. A. Harvey and R. Y. Moore. 1962. “A Demonstration of a Fall in Brain Serotonin Following Central Nervous System Lesions in the Rat.”Biochem. Pharm.,11, 859–866.
—, L. A. Seiden, W. Porcher and R. Y. Moore. 1965. “5-hydroxytryptophan Decarboxylase in Rat Brain: Effect of Hypothalamic Lesions.”Science,147, 887–88.
Karreman, G. 1951. “Contributions to the Mathematical Biology of Excitation with Particular Emphasis on Changes in Membrane Permeability and on Threshold Phenomena.”Bull. Math. Biophysics,13, 189–243.
Landahl, H. D. 1961. “A Note on Mathematical Models for the Interaction of Neural Elements.” —Ibid.,23, 91–97.
— 1965. “A Neural Net Model for Escape Learning.” —Ibid.,27 (Supecial Issue), 317–328.
Rashevsky, N. 1960.Mathematical Biophysics, 3rd Revised Edition, Vols. I and II. New York: Dover Publications, Inc.
Stavraky, G. W. 1961.Supersensitivity Following Lesions of the Nervous System. Toronto: University of Toronto Press.
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Reilly, K.D. Models for reserpine effects on normal and brain-operated animals on a continuous reinforcement bar pressing schedule. Bulletin of Mathematical Biophysics 31, 713–725 (1969). https://doi.org/10.1007/BF02477783
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DOI: https://doi.org/10.1007/BF02477783