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The determination of cell-cycle parameters from measurements of the fraction of labeled mitoses

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Abstract

A method is described for estimating cell-cycle parameters from experimental fraction-of-labeled-mitoses measurements. The method is closely related to that of J. C. Barrett (1970) but is based on the analysis of Brockwell and Trucco (1970) which takes into account population growth in the calculation of theoreticalFLM-functions. Several sets of experimental data are analyzed, among them the data for the Marshall tumor considered by Barrett. It is found that population growth has a small but nevertheless detectable effect on the estimates of the cell parameters.

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Literature

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Author notes

  1. P. J. Brockwell

    Present address: Applied Mathematics Division, 60439, Argonne, Illinois

  2. E. Trucco & R. J. M. Fry

    Present address: Division of Biological and Medical Research, 60439, Argonne, Illinois

Authors and Affiliations

  1. Argonne National Laboratory, 60439, Argonne, Illinois

    P. J. Brockwell, E. Trucco & R. J. M. Fry

Authors
  1. P. J. Brockwell
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  2. E. Trucco
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  3. R. J. M. Fry
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Additional information

Work performed under the auspices of the United States Atomic Energy Commission.

this paper was completed after the untimely death of Dr. Trucco.

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Brockwell, P.J., Trucco, E. & Fry, R.J.M. The determination of cell-cycle parameters from measurements of the fraction of labeled mitoses. Bulletin of Mathematical Biophysics 34, 1–12 (1972). https://doi.org/10.1007/BF02477020

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  • DOI: https://doi.org/10.1007/BF02477020

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