The bulletin of mathematical biophysics

, Volume 28, Issue 2, pp 195–205 | Cite as

Control of the contractility of the myocardium in a feedback system

  • Sidney Roston


Experimental evidence strongly suggests that the contractility of the intact heart in situ, in contrast to that of striated muscle elsewhere in the body, is controlled in a close-cycle system. Thus, the variation of intraventricular pressure during systole follows a complex pattern, whose relative form remains quite constant regardless of the duration of ejection. By use of the single-chambered model of the cardiovascular system, a mathematical representation of a feasible feedback mechanism is developed. The requirement that the feedback system must satisfy mathematical principles eliminates relationships apparently reasonable from a physiological viewpoint. A clinical application which the mathematical development suggests is that early arterial hypertension may arise from an abnormal feedback mechanism with excessively large cardiac output in the initial portion of systole.


Aortic Valve Aortic Pressure Cardiac Contractility Cardiac Contraction Myocardial Contraction 
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Copyright information

© N. Rashevsky 1966

Authors and Affiliations

  • Sidney Roston
    • 1
  1. 1.Department of MedicineUniversity of Louisville School of MedicineLouisville

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