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Estimation of secretory rates of hormones from the specific activities of metabolites which have multiple secreted precursors

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Abstract

The calculation of rates of entry of material into an open system of multiple pools in the steady state from the specific activities of end products, which may be derived from several pools, is described. This analysis may be applied to estimate the rates of secretion of steroid hormones from the specific activities of urinary metabolites which may have various hormones as common precursors. In a previous publication (Gurpideet al., 1963) formulae have been presented by which secretory rates could be calculated after a single injection of the tracers assuming that each of the urinary metabolites was uniquely derived from one of the pools in the system. In the present article similar formulae were derived without this assumption. Consequently, it is shown that, under certain circumstances, non-uniquely derived metabolites can be used to estimate secretory rates, and that it may be unnecessary to consider the pathways of conversion of the hormones to the metabolites or the sites where these conversion occur.

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Author notes

  1. Erlio Gurpide (Career Scientist)

    Present address: Health Research Council, New York

  2. Jonah Mann

    Present address: Department of Mathematics, The City College, New York

Authors and Affiliations

  1. Department of Obstetrics and Gynecology and of Biochemistry, College of Physicians and Surgeons, Columbia University, New York, New York

    Erlio Gurpide (Career Scientist) & Jonah Mann

Authors
  1. Erlio Gurpide
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  2. Jonah Mann
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Additional information

This work was supported in part by Grant AM-00110 of the National Institutes of Health of the United States Public Health Service.

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Gurpide, E., Mann, J. Estimation of secretory rates of hormones from the specific activities of metabolites which have multiple secreted precursors. Bulletin of Mathematical Biophysics 27, 389–406 (1965). https://doi.org/10.1007/BF02476844

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  • DOI: https://doi.org/10.1007/BF02476844

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