Abstract
A population of initially synchronized cells is considered wherein each cell grows according to a dispersionless growth law and the probability of cell division is determined by cell age. The first and second moments of the distribution of birth volumes are considered as functions of time and it is shown that it is impossible for both moments to approach finite, nonzero limits ast→∞. This implies that the volume distribution of the population will not approach a limiting distribution on any finite, nonzero volume interval and that the population will not attain balanced exponential growth. An illustrative example is worked out in detail. The distribution of birth volumes is also analyzed as a function of generation number and it is found that the logarithm of the birth volume in thejth generation is normally distributed asj→∞, with an unbounded variance. Generalizations and implications of these results are briefly discussed.
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Literature
Bell, G. I. 1968. “Cell Growth and Division, III. Conditions for Balanced Exponential Growth in a Mathematical Model.”Biophys. J.,8, 431–444.
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Trucco, E. 1970. “On the Average Cellular Volume in Synchronized Cell Populations.”Bull. Math. Biophysics,32, 459–473.
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Work supported by the U.S. Atomic Energy Commission.
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Trucco, E., Bell, G.I. A note on the dispersionless growth law for single cells. Bulletin of Mathematical Biophysics 32, 475–483 (1970). https://doi.org/10.1007/BF02476766
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DOI: https://doi.org/10.1007/BF02476766