Abstract
Emphasis upon the importance of homeostatic feedback has drawn attention away from the complexity of biological processes. A study of glucose metabolism indicates the importance of open-cycle as well as closed-cycle mechanisms. Besides the glucose-dependent mechanism of insulin secretion, many open-cycle processes involving the liver, adrenal glands and kidneys, play important roles in the variation of blood glucose. In addition, glucose utilization by the tissues is essentially open-cycle in nature.
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Roston, S. Glucose metabolism—A “mixed-cycle” system. Bulletin of Mathematical Biophysics 23, 99–103 (1961). https://doi.org/10.1007/BF02476577
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DOI: https://doi.org/10.1007/BF02476577