A fit to nerve membrane rectification curves with a double-dipole-layer membrane model
- 43 Downloads
Following Wei's suggestion that nerve stimulation and conduction properties are due to dipole layers at the two membrane surfaces (Wei, 1969), we have done steady-state electro-diffusion calculations in the constant field approximation for a simple double-dipole-layer model. We are thereby able to quantitatively fit the recent potassium iso-osmotic rectification curves of Gilbert and Ehrenstein for the squid giant axon membrane. For the squid axon membrane in a natural ion environment, only the outside dipole layer is present in the fit to the data.
KeywordsConstant Electric Field Negative Resistance Inside Layer Squid Giant Axon Nerve Membrane
Unable to display preview. Download preview PDF.
- Cole, K. S. 1968.Membranes, Ions and Impulses. Berkeyley: Univ. of Calif. Press.Google Scholar
- Dowben, R. M., Ed. 1969.Biological Membranes. Boston: Little, Brown and Co.Google Scholar
- Gilbert, D. L., and G. Ehrenstein. 1969. “Effect of Divalent Cations on Potassium Conductance of Squid Axons: Determination of Surface Charge.”Biophys. J.,9, 447–463.Google Scholar
- Hodgkin, A. L., A. F. Huxley and B. Katz. 1952. “Measurement of Current-Voltage Relations in the Membrane of the Giant Axon of Loligo.”J. Physiol.,116, 424–447.Google Scholar
- Wei, L. Y. 1969. “Molecular Mechanisms of Nerve Excitation and Conduction.”Bull. Math. Biophys.,31, 39–58.Google Scholar