A fit to nerve membrane rectification curves with a double-dipole-layer membrane model
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Following Wei's suggestion that nerve stimulation and conduction properties are due to dipole layers at the two membrane surfaces (Wei, 1969), we have done steady-state electro-diffusion calculations in the constant field approximation for a simple double-dipole-layer model. We are thereby able to quantitatively fit the recent potassium iso-osmotic rectification curves of Gilbert and Ehrenstein for the squid giant axon membrane. For the squid axon membrane in a natural ion environment, only the outside dipole layer is present in the fit to the data.
KeywordsConstant Electric Field Negative Resistance Inside Layer Squid Giant Axon Nerve Membrane
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- Cole, K. S. 1968.Membranes, Ions and Impulses. Berkeyley: Univ. of Calif. Press.Google Scholar
- Dowben, R. M., Ed. 1969.Biological Membranes. Boston: Little, Brown and Co.Google Scholar
- Gilbert, D. L., and G. Ehrenstein. 1969. “Effect of Divalent Cations on Potassium Conductance of Squid Axons: Determination of Surface Charge.”Biophys. J.,9, 447–463.Google Scholar
- Hodgkin, A. L., A. F. Huxley and B. Katz. 1952. “Measurement of Current-Voltage Relations in the Membrane of the Giant Axon of Loligo.”J. Physiol.,116, 424–447.Google Scholar
- Wei, L. Y. 1969. “Molecular Mechanisms of Nerve Excitation and Conduction.”Bull. Math. Biophys.,31, 39–58.Google Scholar