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The effect of restricted intramolecular energy flow on the rate of one-substrate enzyme catalyzed reaction

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Abstract

We assume that the free intramolecular energy flow (intramolecular vibrational energy redistribution—IVR) between bonded substrate and enzyme can be restricted due to the presence of a metal atom near the binding site of enzyme. This restriction can represent one of the factors of enzyme catalysis. The concentration of energy evolved during the formation of enzyme-substrate complex in the bonded substrate enhances the reaction rate by several orders of magnitude in comparison with the case of free dissipation of evolved energy into the enzyme.

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Authors and Affiliations

  1. Institute of Inorganic Chemistry, Academy of Sciences of the Czech Republic, 250 68, Řež near Prague, Czech Republic

    M. Šolc & J. Hostomský

Authors
  1. M. Šolc
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  2. J. Hostomský
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Šolc, M., Hostomský, J. The effect of restricted intramolecular energy flow on the rate of one-substrate enzyme catalyzed reaction. React Kinet Catal Lett 67, 53–58 (1999). https://doi.org/10.1007/BF02475827

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  • DOI: https://doi.org/10.1007/BF02475827

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