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Mechanism of oxidation of diazepam by 1-chlorobenzotriazole in acidic medium. A kinetic approach

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Abstract

The kinetics of oxidation of diazepam (DZ) by 1-chlorobenzotriazole (CBT) has been studied in HClO4 medium in the temperature range of 293–323 K. The reactions followed a first order dependence on [CBT], fractional order each in [H+] and [DZ]. Activation parameters were evaluated. A negative entropy of activation indicated the involvement of a rigid complex in the activated state. Variation of reaction rate with dielectric constant and the ionic strength are consistent with a mechanism involving the decomposition of a dipole in the rate-determining step. Rate equation is derived to account for the observed kinetic data and the proposed reaction mechanism.

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Authors and Affiliations

  1. Department of Chemistry, Central College, Bangalore University, 560 001, Bangalore, India

    N. Nanda, B. S. Sheshadri & S. M. Mayanna

Authors
  1. N. Nanda
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  2. B. S. Sheshadri
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  3. S. M. Mayanna
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Nanda, N., Sheshadri, B.S. & Mayanna, S.M. Mechanism of oxidation of diazepam by 1-chlorobenzotriazole in acidic medium. A kinetic approach. React Kinet Catal Lett 67, 35–41 (1999). https://doi.org/10.1007/BF02475824

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  • DOI: https://doi.org/10.1007/BF02475824

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