The effects of the dynamic state of the cytoskeleton on neuronal plasticity
The effects of degrading and stabilizing microtubules and microfilaments on the formation of plastic reactions were studied in isolated nerve cells from the molluskLymnaea stagnalis. Degradation of the cytoskeleton affected the performance, retention, and repeated acquisition of plastic reactions. Stabilization of microtubules led to the appearance of a relationship between the dynamics of the development and retention of plastic reactions and the series of stimulation. Stabilization of microfilaments led to transient plastic reaction, along with long-term reactions. These results show that rearrangements of the cytoskeleton have a key role in the processes of neuronal plasticity.
Key WordsNeuron plasticity cytoskeleton learning
Unable to display preview. Download preview PDF.
- 1.L. Sh. Ganelina and T. P. Nekrasova, “Protein kinase C and its role in normal and transformed cells,”Tsitologiya,31, No. 2, 131–147 (1989).Google Scholar
- 2.D. A. Moshkov,Neuron Adaptation and Ultrastructure [in Russian], Nauka, Moscow (1985).Google Scholar
- 3.A. S. Ratushnyak, R. A. Zapara, A. A. Zharkikh, and O. A. Tatushnyak, “The effects of changes in dynamic equilibrium in microtubule and microfilament systems on plastic reactions of neurons,”Zh. Vyssh. Nerv. Deyat.,46, No. 2, 355–362 (1995).Google Scholar
- 5.Yu. V. Chistyakova and E. V. Parfenova, “Ca protease—an enzyme involved in the metabolism of cytoskeletal proteins in the olfactory pavement of vertebrates,”Tsitologiya,11, 1345–1352 (1989).Google Scholar
- 6.Ch. Aoki and Ph. Siekevitz, “Ontogenetic changes in the cyclic adenosine-3,5-monophosphate-stimulatable phosphorylation of cat visual cortex proteins, particularly of microtubule-associated protein 2 (MAP2): effects of normal and dark rearing and of the exposure to light,”J. Neurosci.,5, No. 9, 2465–2483 (1985).PubMedGoogle Scholar
- 7.V. Bennet, K. Gardner, and J. Steiner, “Brain adducin: a protein kinase C substrate that may mediate site-directed assembly at the spectrin-actin junction,”J. Biol. Chem.,263, No. 12, 5860–5869 (1988).Google Scholar
- 20.R. Prekeris, M. W. Mayhew, J. B. Cooper, and D. M. Terrian, “Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in regulation of synaptic function,”J. Cell. Biol.,132, No. 1-2, 77–90 (1996).PubMedCrossRefGoogle Scholar
- 21.E. M. Quinlan and S. Halpaint “Emergence of activity-dependent, bidirectional control of microtubule-associated protein MAP2 phosphorylation during postnatal development,”Neurosci.,16, No. 23, 7627–7637 (1996).Google Scholar