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Cyclosporine-associated microangiopathic hemolytic anemia in a renal transplant recipient

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Abstract

A case of microangiopathic hemolytic anemia (MHA) associated with the immunosuppressive agent, cyclosporine, is reported herein. The patient manifested anemia with red blood cell fragmentation, hypertension, thrombocytopenia, elevation of serum LDH levels and glomerular capillary thromboses within a few days of his transplantation. Extensive treatments with urokinase and heparin proved ineffective and graftectomy was performed 7 days after his transplantation. Immunofluorescent staining failed to show immunoglobulin (IgG or IgM) or complement (C3) deposition within the glomeruli, which discriminated MHA from acute humoralvascular rejection.

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Authors and Affiliations

  1. The Second Department of Surgery, Kyoto Prefectural University of Medicine, 465 Hirokoji, Kawaramachi, Kamikyo-ku, 602, Kyoto City, Kyoto, Japan

    Norio Yoshimura MD, PhD, Takahiro Oka, Yoshihiro Ohmori, Ichiro Aikawa, Tadaki Yasumura, Suguru Matsui, Takashi Hamashima & Chol Joo Lee

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  1. Norio Yoshimura MD, PhD
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  2. Takahiro Oka
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  3. Yoshihiro Ohmori
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  4. Ichiro Aikawa
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  5. Tadaki Yasumura
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  6. Suguru Matsui
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  7. Takashi Hamashima
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  8. Chol Joo Lee
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Yoshimura, N., Oka, T., Ohmori, Y. et al. Cyclosporine-associated microangiopathic hemolytic anemia in a renal transplant recipient. The Japanese Journal of Surgery 19, 223–228 (1989). https://doi.org/10.1007/BF02471590

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  • DOI: https://doi.org/10.1007/BF02471590

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