Abstract
A woman was operated on for a nonepithelial malignant tumor of the left leg and subsequently, for an epithelial carcinoma of the right breast and a borderline malignant tumor of the right ovary. She also developed a giant cavernous hemangioma that caused disseminated intravascular coagulation syndrome, which necessitated a left trisegmentectomy of the liver. Her family history suggested a hereditary predisposition to diverse malignant neoplasms, and also to giant cavernous hemangioma of the liver. Immunological evaluation disclosed selective inhibition of natural killer cell activity. Hormonal and hereditary factors are discussed in relation to the development of multiple primary tumors and giant cavernous hemangioma of the liver.
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References
Warren S, Gate O. Multiple primary malignant tumors; survey of literature and statistical study. Am J Cancer 1932; 16: 1358–1414.
Warren S, Ehrenreich T. Multiple primary malignant tumors and susceptibility to cancer. Cancer Res 1944; 4: 554–570.
Moertel CG, Dockerty MB, Baggenstoss AH. Multiple primary malignant neoplasms; 1, Introduction and presentation of data. Cancer 1961; 14: 221–230.
Ko HS, Minkarious EF. Immunologic abnormalities in a patient with multiple neoplasms. CMA Journal 1976; 114: 917–919.
Mulvihill JJ, McKeen EA. Discussion: Genetics of multiple primary tumors. Cancer 1977; 40: 1867–1871.
Strong LC. Genetics and environmental interactions. Cancer 1977; 40: 1861–1866.
Lemon HM. Experimental basis for multiple primary carcinogenesis by sex hormones, a review. Cancer 1977; 40: 1825–1832.
Sanders FK, Phil D. Experimental carcinogenesis. Induction of multiple tumors by viruses. Cancer 1977; 40: 1841–1844.
Penn I. Second malignant neoplasms associated with immunosuppressive medications. Cancer 1976; 37: 1024–1032.
Thompson DK, Li FP, Cassady JR. Breast cancer in a man 30 years after radiation for metastatic osteogenic sarcoma. Cancer 1979; 44: 2362–2365.
Morley JE, Myers JB, Sack FS, Kalk F, Epstein EE, Lannon J. Enlargement of cavernous hemangioma associated with exogenous administration of oestrogens. S Afr Med J 1974; 6: 695–697.
Nobles RL, Hochachka BC, King D. Spontaneous and estrogen-produced tumors in Nb rat and their behaviour after transplantation. Cancer Res 1975; 35: 766–780.
Old LJ, Boyse EA. Immunology of experimental tumors. Ann Rev Med 1964; 15: 167–186.
Haliotis T, Roder J, Klein M, Ortaldo J, Fauci AS, Herberman RB. Chédiak-Higashi gene in humans I. Impairment of Natural-Killer function. J Exp Med 1980; 151: 1039–1048.
Ziegler (Löms) HW, Kay NE, Zarling JM. Deficiency of natural killer cell activity in patients with chronic lymphocytic leukemia. Int J Cancer 1981; 27: 321–327.
Lotzova E, Savary CA, Keating MJ, Hester JP. Defective NK cell mechanism in patients with leukemia. In: Herberman RB, Callewaert DM, eds. Mechanisms of cytotoxicity by NK cells. Orlando Academic press, Inc. 1985; 507–519.
Kelein M, Roder J, Haliotis T, Korec S, Jett JR, Herberman RB, Katz P, Faugi AS. Chédiak-Higashi gene in humans II. The selectivity of the defect in Natural-Killer and antibody-dependent cell-mediated cytotoxicity function. J Exp Med 1980; 151: 1049–1058.
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Tomiyama, T., Uchida, K., Yoshida, K. et al. Giant cavernous hemangioma of the liver and multiple primary malignant tumors in a patient with suspected familial inhibition of natural killer cell activity —A case report—. The Japanese Journal of Surgery 19, 216–222 (1989). https://doi.org/10.1007/BF02471589
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DOI: https://doi.org/10.1007/BF02471589