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Thermotolerance of xenografted human gastric cancer

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Abstract

To compare the thermotolerancein vivo of two human gastric cancers with different doubling times, the xenografted tumors were warmed twice at 43.5±0.1°C in a water bath for 20 minutes at a predetermined interval. In the tumors with doubling times of 5.2 and 10.9 days, a 7-day interval heat treatment resulted in a prolongation in tumor tripling times by 156 per cent and 132 per cent, respectively, compared with a single heat treatment for 40 minutes. On the contrary, two heat treatments given at intervals of 3 to 5 days had a short tumor tripling time, compared to that of the 40-minute single treatment. Thus, the thermotolerance of these human gastric cancers gradually increased to a maximum within a 3- to 4-day interval and disappeared completely after a 7-day interval. These results indicate that the times required to reach maximal thermotolerance in these human gastric cancers were longer than those previously demonstrated for human and rodent cancer cell linesin vitro. The development and decay of thermotolerance in these human gastric cancers need to be considered in the design of multiple-fractionated regimens.

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Authors and Affiliations

  1. The Division of Surgery, Matsudo Municipal Hospital, Matsudo, Chiba, Japan

    Makoto Takahashi

  2. The Department of Oncologic Surgery, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

    Masahide Fujita & Tetsuo Taguchi

  3. First Department of Surgery, School of Medicine, Chiba University, 1-8-1, Inohana, 280, Chiba, Japan

    Shigeru Fujimoto MD, Masayasu Ohta, Ram Dhoj Shrestha, Masashi Kokubun, Kokuriki Kobayashi, Sohzaburo Kiuchi, Chiyuki Konno & Katsuji Okui

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  1. Shigeru Fujimoto MD
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  2. Masayasu Ohta
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  3. Ram Dhoj Shrestha
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  4. Masashi Kokubun
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  5. Kokuriki Kobayashi
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  6. Sohzaburo Kiuchi
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  7. Chiyuki Konno
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  8. Makoto Takahashi
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  9. Masahide Fujita
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  10. Tetsuo Taguchi
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  11. Katsuji Okui
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Fujimoto, S., Ohta, M., Shrestha, R.D. et al. Thermotolerance of xenografted human gastric cancer. The Japanese Journal of Surgery 19, 203–207 (1989). https://doi.org/10.1007/BF02471586

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  • DOI: https://doi.org/10.1007/BF02471586

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