Abstract
Fourteen out of 301 patients who underwent allogeneic kidney transplantations, between April, 1970 and December, 1987, received second kidney allografts, including 4 living and 10 cadaveric grafts. The survival of the second grafts transplanted in those 14 recipients was superior to that of the first grafts transplanted in the other 287 recipients. Furthermore, the survival of the second grafts from 4 years onwards was significantly higher than that of the first grafts, in spite of a higher population of cadaveric grafts used in the second transplantation than in the first. Although it was impossible to determine the main factor which induced the improved survival of the second grafts when compared with that of the the first, a combination of beneficial factors, such as a high rate of living related transplantation resulting in long-term graft survival of the first transplantation, the administration of immunosuppressive drugs during the period of re-hemodialysis and blood transfusion prior to the second transplantation, was considered to be the reason why successful second graft survival was achieved.
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Yasumura T, Ohmori Y, Aikawa I, Fukuda M, Suzuki S, Nakai I, Matsui S, Oka T. Improved outcome of renal transplantation with cyclosporine compared with azathioprine— Experience in 33 recipients followed for over one year—. Jpn J Surg 1986; 16: 181–188.
Opelz G, Terasaki PI. Recipient selection for renal retransplantation. Transplantation 1976; 21: 483–488.
Kounz SL, Belzer FO. The fate of patients after renal transplantation, graft rejection, and retransplantation. Ann Surg 1972; 176: 509–520.
Freier DT, Haines RF, Rosenzweig J, Niederhuber J, Konnak J, Turcotte JG. Sequential renal transplant: Some surgical and immunological implications on management of the first homograft. Surgery 1976; 79: 262–267.
Slooff MJH, Tegzes AM, Fidler VJ, v.d. Voort-Beelen JM, Krom RAF, Meijer S, Kootstra G. Cadaveric kidney retransplantation. Is it justified? Proc EDTA 1979; 16: 347–351.
Rook A, Prichard S, Morehouse DD, Gurrmann RD, Meakins JL, Hutchinson TA. Results of retransplantation in individuals who received two successive cadaver kidneys. Canad J Surg 1979; 22: 519–522.
Frisk B, Ahlmen J, Brynger H, Sandberg L, Gelen LE. Outcome of repeated renal regraftment. Proc EDTA 1980; 17: 462–466.
Marni A, McMaster P, Evans DB, Calne RY. Is it really worth retransplanting patients? Proc EDTA 1979; 16: 352–358.
Opelz G, Terasaki PI. Absence of immunization effect in human-kidney retransplantation. N Engl J Med 1978; 299: 369–374.
Ascher NL, Ahrenholz DH, Simmons RL, Najarian JS. 100 second renal allografts from a single transplantation institution. Transplantation 1979; 27: 30–34.
Gifford RRM, Sutherland DER, Fryd DS, Simmons RL, Najarian JS. Duration of first renal allograft survival as indicator of second allograft outcome. Surgery 1980; 88: 611–618.
Casali R, Simmons RL, Ferguson R, Mauer SM, Kjellstrand CM, Buselmeier TJ, Najarian JS. Factors related to success or failure of second renal transplants. Ann Surg 1976; 184: 145–154.
Persijn GG, Lansbergen Q, D'Amaro J, van Rood J. Blood transfusion and second kidney allograft survival. Transplantation 1981; 12: 392–394.
Dewan PJ, Murray S, Wilkinson R. A new finding relating to transfusion and renal transplants. Transplantation 1980; 29: 379–380.
Frisk B, Smith L, Sandberg L, Brynger H. Prognostic factors at the time of renal retransplantation. Proc EDTA 1983; 20: 280–285.
Gustafsson A, Groth CG, Halgrimson CG. The fate of failed renal homografts retained after retransplantation. Surg Gynecol Obstet 1973; 137: 40–42.
Sanfilippo F, Goeken N, Niblack G, Scornik J, Vaughn WK. The effect of first cadaver renal transplant HLA-A, B match on sensitization levels and retransplant rates following graft failure. Transplantation 1987; 43: 240–244.
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Yasumura, T., Ohmori, Y., Aikawa, I. et al. The successful outcome of second kidney transplantation and its contributing factors. The Japanese Journal of Surgery 19, 163–170 (1989). https://doi.org/10.1007/BF02471580
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DOI: https://doi.org/10.1007/BF02471580