Abstract
One hundred and twenty-one patients with gastric cancer of Borrman IV (type 4) were classified into two types according to the macroscopic appearance of their tumors, namely, those tumors with giant folds (type G, n=84) and those without giant folds (type P, n=37). A large percentage of the cases in both type groups had advanced stage carcinoma. Type G was found to be predominant in young women and the incidence of high-grade lymph node metastasis was higher in type G than in type P. Histochemically, it was shown that the tumor interstitium of type G contained obviously many more acid mucopolysaccharides (AMPS) than the localized Borrman II (type 2) gastric cancer, which was used as a control. The results of enzymatic digestion tests suggested that the amounts of hyaluronic acid, chondroitin sulfate, and sialic acid were greater in type G than in type P or the localized type, the differences involved being marked between type G and the localized type.
Similar content being viewed by others
References
Iwanaga T, Furukawa H, Taniguchi H, Ishiguro S. Extension modes in Borrmann-4 stomach carcinoma estimated by macroscopic appearances. Gan no Rinsho (Jpn J Cancer Clin) 1983; 29: 120–124. (English Abst.)
Shimoda T, Hirota E. Pathological study of diffuse infiltrative carcinoma of stomach. I to Cho (Stomach and Intestine) 1976; 11: 1265–1274. (English Abst.)
Watanabe T. Clinical, histopathological and histochemical study of Borrmann type IV carcinoma of the stomach. Nippon Rinsho Geka Igaku Gakkai Zasshi (J Jpn Soc Clin Surg) 1979; 40: 242–258.
Nomura H, Nishi M. A clinical pathological study on the patterns of development of gastric cancer of Borrmann 4 type. Nippon shokakibyo Gakkai Zasshi (Jpn J Gastroent) 1979; 76: 831–839. (English Abst.)
Nakamura K, Kato Y, Misono T, Sugano H, Sugiyama N, Baba Y, Maruyama M, Takagi K. Growing process to carcinoma of linitis plastica type of the stomach from cancer-development. I to Cho (Stomach and Intestine) 1980; 15: 225–234. (English Abst.)
Kodama Y, Soejima K, Matsusaka T, Miyazaki M, Yoshimura K, Inoguchi K. Clinicopathological analysis of Borrmann type 4 gastric carcinoma. Gan no Rinsho (Jpn J Cancer Clin) 1977; 23: 191–197. (English Abst.)
Hirota T, Mizutani Y, Ueno A, Itabashi M, Hirata K, Maruyama K, Kitaoka H. Clinicopathological characteristics and morphogenesis of the scirrhous gastric cancer. Rinsho Geka (J Clin Surg) 1986; 41: 151–160.
Takeuchi J. Growth-promoting effect of acid mucopolysaccharides on Ehrlich ascites tumor. Cancer Res 1966; 26: 797–802.
Hano K, Nishino Y. Pharmacological studies on the metabolism of mucopolysaccharides in tumor cells. Gann 1965; 56: 49–58.
Kimata K, Honma Y, Okayama M, Oguri K, Hozumi M, Suzuki S. Increased synthesis of hyaluronic acid by mouse mammary carcinoma cell variants with high metastatic potential. Cancer Res 1983; 43: 1347–1354.
Ozzello L, Speer FD. The mucopolysaccharides in the normal and diseased breast. Their distribution and significance. Am J Path 1958; 34: 993–1009.
Majewska H, Majewski C, Radzicki J, Leja Z. Acid mucopolysaccharides in the ground substance of connective tissue in cancer of the skin. Cancer 1965; 18: 388–390.
Galambos JT. Acid mucopolysaccharides and cirrhosis of the liver. Gastroenterology 1966; 51: 65–74.
Ishikawa O, Matsui Y, Aoki Y, Iwanaga T, Terasawa T, Wada A, Tateishi R, Akedo H. A histochemical study of the intracytoplasmic mucosubstances on chronic pancreatitis and pancreatic carcinoma. Nippon Shokaki Geka Gakkai Zasshi (Jap Soc Gastroenterol Surg) 1980; 77: 1635–1645.
Kato Y. Histochemical study of mucosubstances in pancreatic carcinoma induced in rats and hamsters. Osakashi Igaku Zasshi (J Osaka City Med C) 1984; 33: 353–380. (English Abst.)
Yamamoto S. Clinical and histochemical studies on resected pancreatic carcinoma—with reference to mucosubstances in the tumor tissue. Osakashi Igaku Zasshi (J Osaka City Med C) 1985: 34: 169–202. (English Abst.)
Kino I. Pathology and histogenesis of gastric scirrhous carcinoma. Can no Rinsho (Jpn J Cancer Clin) 1984; 30: 703–709. (English Abst.)
Japanese Research Society for Gastric Cancer. The general rules for the gastric cancer study in surgery and pathology (The 11th edition). Tokyo: Kanehara Shuppan, 1985.
Koizumi T, Nakamura N. Tumor and acid mucopolysaccharides. (author's transl.) Nippon Rinsho (Jpn J of Clin Med) 1975; 33: 1950–1955.
Spicer SS, Leppi TJ, Stoward PJ. Suggestions for a histochemical terminology of carbohydrate-rich tissue components. J Histochem Cytochem 1965; 13: 599–603.
Reid L, Champ JR. The biochemical and histochemical nomenclature of mucus. Br Med Bull 34: 5–8, 1978.
Kanazawa K. Histochemical differentiation of acid mucopolysaccharides—using AMPS-degracing enzymes and sialidase. Ketsugo Soshiki (Connective Tissue) 1974; 6: 17–37.
Ozzello L, Lasfargues EY, Murray MR. Growth-promoting activity of acid mucopolysaccharides on a strain of human mammary carcinoma cells. Cancer Res 1960; 20: 600–604.
Kawase K. Histopathological histochemical and biochemical studies on acid mucopolysaccharides in the cancer tissue of stomach. Nippon Geka Gakkai Zasshi (J Jpn Surg Soc) 1977; 78: 1037–1049. (English Abst.)
Takeuchi T. Biochemical studies on the scirrhous carcinoma of the stomach. (author's transl.) Kulinika (Clinica) 1983; 10: 330–334.
Hanabusa N, Okajima K, Fujii Y, Araki K, Ishikawa J, Ito M, Tsuboi J, Okabayashi H. Histochemical studies on vascular invasion and connective tissue in gastric carcinoma. Gan no Rinsho (Jpn J Cancer Clin) 1976; 22: 761–770. (English Abst.)
Nishida S, Watanabe Y, Kobayashi A, Ohtaka Y. A histochemical observation on the stroma of cancerous tissue and the spontaneous stroma—with regard to findings of AMPS and sialic acid. Ketsugo Soshiki (Connective Tissues) 1973; 5: 61–62.
Lipton A, Harvey HA, Delong S, Allegra J, White D, Allegra M, Davidson EA. Glycoproteins and human cancer. 1. Circulating levels in cancer serum. Cancer 1979; 43: 1766–1771.
Yagi J. The clinical study of serum sialic acid in patients with gastric cancer. Nippon Geka Gakkai Zasshi (J Jpn Surg Soc) 1979; 80: 248–260.
Matsukuchi T, Tomoda H, Furusawa M, Higuchi K. An evaluation of serum sialic acid levels in patients with gastric and colonic carcinoma. (author's transl.) Rinsho Byori (Jap J Clin Path) 1983; 53–57: 96–101.
Ogoshi K, Kondoh Y, Tajima T, Mitomi T. Serum sialic acid levels in patients with stomach cancer with reference of cellular immunity and other glycoproteins. Nippon Shokakibyo Gakkai Zasshi (Jpn J Gastroent) 1983; 80: 2352–2356. (English Abst.)
Tan CH, Ng FH, Ti TK. Serum sialic acid levels in gastrointestinal and other cancers. Asian Med J 1984; 27: 404–409.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sowa, M., Kato, Y., Nishimura, M. et al. Clinico-histochemical studies on type 4 carcinoma of the stomach—With special reference to mucopolysaccharides and sialic acid in tumor tissue. The Japanese Journal of Surgery 19, 153–162 (1989). https://doi.org/10.1007/BF02471579
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02471579