The Japanese journal of surgery

, Volume 18, Issue 6, pp 694–704 | Cite as

Studies on the energy expenditure following surgical stress (II. The correlation between energy expenditure and hormonal changes)

  • Motohiko Naruko
  • Yoshitaka Ogawa
  • Yoshihiro Kido
  • Hideki Niwa
  • Yoshio Abe
  • Mitsugu Kobayashi
  • Takesada Mori
  • Takehiko Tanaka
Original Articles

Abstract

The correlation between energy expenditure and hormonal changes following surgical stress was studied using rats. Blood concentrations of catecholamine, insulin, corticosterone, glucagon, T3, and T4 were compared between the rats (IIa and IIb) in the ebb phase and those (III and IV) in the flow phase, 6 hours after being inflicted with a burn. Noradrenaline was higher, though not significantly, and glucagon was significantly higher in the latter groups than in the former groups. When glucagon was administered to the rats in the ebb phase, RME increased significantly. From these results, it is suggested that glucagon plays an important role in the transition from ebb phase to flow phase.

Key Words

energy expenditure surgical stress hormonal changes 

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References

  1. 1.
    Naruko M, Ogawa Y, Kido Y, Niwa H, Abe Y, Kobayashi M, Mori T, Tanaka T. Studies on the energy expenditure following surgical stress. (1. The effects of the severity of stress and the administration of nutrients). Jpn J Surg 1988; 18: 194–202.PubMedCrossRefGoogle Scholar
  2. 2.
    Yui Y, Kimura M, Itokawa Y, Kawai C. Ultramicro method for the determination of picogram amounts of norepinephrine and epinephrine by high-performance liquid chromatography. Chromatography 1979; 177: 376–379.CrossRefGoogle Scholar
  3. 3.
    Tominaga M, Maruhashi S, Ebitani I, Sasaki H. A study on glucagon RIA Kit. Horumon to Rinsho (Clinical Endocrinology) 1980; 28: 1323–1327. (In Japanese)PubMedGoogle Scholar
  4. 4.
    Den K, Tomita M, Miyake Y, Yamaguchi N, Fukusawa Teramoto S, Takagi S. Studies of material and fetal 11-Deoxycorticosterone, corticosterone, 18-Hydroxy corticosterone and aldosterone in normal and toxemic pregnancy. Endocrinol Japon 1980; 27: 703–708.Google Scholar
  5. 5.
    Satoh Y, Yano Y, Fujii A, Akai T, Okuda K. Determination of Serum Triiodothyronine by T-3 RIA III and its Clinical Application in various thyroid states. Shinryo to Shinyaku (Medical Consultation and New Remedies) 1981; 18: 241–245. (in Japanese)Google Scholar
  6. 6.
    Kanao K, Shizumori I, Toe Y, Yagi Y, Koyama C. Investigation of measurement method for serum thyroxine (T4) by radioimmunoassay used polyethyleneglycol (PEG). Radioisotopes 1977; 26: 45–48. (in Japanese).Google Scholar
  7. 7.
    Steiger E, Vars HM, Dudrick SJ. A technique for long term intravenous feeding in unrestrained rats. Arch Surg 1972; 104: 330–332.PubMedGoogle Scholar
  8. 8.
    Groves AC, Griffiths J, Lenng F, Meek RN. Plasma catecholamine in patients with serious postoperative infection. Ann Surg 1973; 178: 102–113.PubMedGoogle Scholar
  9. 9.
    Halter JR, Pflug AE, Porte D Jr. Mechanism of plasma catecholamine increases during surgical stress in man. J Clin Endocrinol Metab 1977; 45: 936–944.PubMedCrossRefGoogle Scholar
  10. 10.
    Oyama T, Saito T, Isomatsu T. Plasma levels of ACTH and cortisol in man during diethyl ether anesthesia and surgery. Anesthesiol 1968; 29: 559–564.CrossRefGoogle Scholar
  11. 11.
    Russel RCG, Walker CJ, Bloom SR. Hyperglucagonemia in surgical patients. Brit Med J 1975; 1: 10–12.CrossRefGoogle Scholar
  12. 12.
    Wilmore DW, Lindsey CA, Moylan JA, Faloona GR, Pruitt BA, Unger RH. Hyperglucagonemia after burns. Lancet 1974; 1: 73–75.PubMedCrossRefGoogle Scholar
  13. 13.
    Moore FD. Metabolic care of the surgical patient. Philadelphia: W.B. Saunders 1959; 25–28.Google Scholar
  14. 14.
    Alberti KGMM. Hormonal changes in trauma: Role of cortisol. In: Richard ERCS, Kinney FM, eds. Nutritional aspects of care in the critically ill. London and New York; Churchill Livingstone 1977; 225–239.Google Scholar
  15. 15.
    Kido Y. Influence of nutrition on the metabolic response to surgical stress. Osaka Daigaku Igaku Zasshi (Medical Journal of Osaka University) 1984: 34: 39–54. (in Japanese)Google Scholar
  16. 16.
    Wilmore DW, Long JM, Mason AD, Skreen RW, Pruitt BA Jr. Catecholamines: Mediator of the hypermetabolic response to thermal injury. Ann Surg 1974; 180: 653–659.PubMedGoogle Scholar
  17. 17.
    Harrison TS, Seton JF, Feller I. Relationship of increased oxygen consumption to catecholamine excretion in thermal burns. Ann Surg 1967; 165: 169–172.PubMedGoogle Scholar
  18. 18.
    Deavers DR, Musacchia XJ. The function of glucocorticoids in thermogenesis. Fed Proc 1979; 38: 2177–2181.PubMedGoogle Scholar
  19. 19.
    Alberti KGMM, Bladstone GF, Foster KJ, Johnstone DG. Relative role of various hormones in mediating the metabolic response to injury. Journal of Parenteral and Enteral Nutrition 1980; 4: 141–146.PubMedGoogle Scholar
  20. 20.
    Bessey PQ, Watters JM, Aoki TT, Wilmore DW. Combined hormonal infusion simulates the metabolic response to injury. Ann Surg 1984; 200: 264–281.PubMedGoogle Scholar
  21. 21.
    Issekutz B Jr, Allen M. Effect of catecholamine and methylprednisolone on carbohydrate metabolism of dogs—Metabolism of dogs. Metabolism 1974; 21: 48–59.CrossRefGoogle Scholar
  22. 22.
    Ostman J, Efendic S. Catecholamines and metabolism of human adipose tissue. Acta Med Scand 1975; 187: 471–476.CrossRefGoogle Scholar
  23. 23.
    Nakamura T, Kato S, Ichihara A. Glucagon and glucose as major regulations of glycogen metabolism in primary cultured rat hepatocytes. J Biochem 1984; 95: 1691–1696.PubMedGoogle Scholar

Copyright information

© The Japan Surgical Society 1988

Authors and Affiliations

  • Motohiko Naruko
    • 2
  • Yoshitaka Ogawa
    • 2
  • Yoshihiro Kido
    • 2
  • Hideki Niwa
    • 2
  • Yoshio Abe
    • 2
  • Mitsugu Kobayashi
    • 2
  • Takesada Mori
    • 2
  • Takehiko Tanaka
    • 1
  1. 1.the Department of Nutrition & PhysiochemistryOsaka University Medical SchoolOsakaJapan
  2. 2.The Second Department of SurgeryOsaka University Medical SchoolOsakaJapan

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