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The indications of chemosensitivity tests against various anticancer agents

The Japanese journal of surgery volume 18, pages 647–652 (1988)Cite this article

Abstract

In order to determine the indications of chemosensitivity tests against various anticancer agents, clinical trials of 4 different assays, namely; nude mouse isotope assay (NMIA), subrenal capsule assay (SRCA), human tumor clonogenic assay (HTCA) and adenosine triphosphate inhibition assay (ATPA), were performed on 391 patients. Analysis of the correlation between assay results and clinical effects presented the possibility of determining the indications as follows; (1) The positive clinical respons of mitomycin C (MMC) should be predicted by ATPA; (2) The clinical tumor resistance against MMC should be predicted by SRCA; (3) Concerning 5-fluorouracil (5-FU) the chemosensitivity test (ATPA) should only be used for the detection of tumor resistance in the assay; (4) The poor results of this study indicated the difficulty of correctly estimating the effects of cyclophosphamide (CPM); (5) The perfect prediction of clinical effects in this trial indicated that cis-DDPlatinum (CDDP) should be estimated by SRCA; (6) The positive clinical tumor response against adriamycin (ADM) should be predicted by SRCA, while the negative one should be predicted by HTCA; and (7) ATPA showed good potential for estimatating not only time dependent drugs such as 5-FU, but also cytotoxic drugs.

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References

  1. Hamburger AE, Salmon SE. Primary bioassay of human tumor stem cells. Science 1977; 197: 641–663.

    Google Scholar 

  2. Tani T, Nishimawari K, Noso Y, Hattori T. Chemosensitivity test. In: Shimosato S, Tamaki K, eds. Human cancer and nude mouse. Tokyo: Ishiyaku shuppan, 1982; 287–294. (in Japanese)

    Google Scholar 

  3. Bogden AE, Cobb WR, Lepage DJ, Haskell PM, Gulkin TA, Ward A, Kelton DE, Esber HJ. Chemotherapy responsiveness of human tumors as first transplant generation xenografts in the normal mice: six-day subrenal capsule assay. Cancer 1981; 48: 10–20.

    PubMed  CAS  Article  Google Scholar 

  4. Nishiyama M, Nosoh Y, Yamaguchi M, Hirabayashi N, Toge T, Niimoto M, Hattori T. Comparative study on nude mice isotope assay (NM-IA) and subrenal capsule assay (SRCA) sensitivity tests of anticancer agents. Jpn J Surg 1987; 17: 99–103.

    PubMed  CAS  Article  Google Scholar 

  5. Nishiyama M, Nosoh Y, Yamaguchi M, Hirabayashi N, Toge T, Niimoto M, Hattori T. Prediction of individual tumor chemosensitivity in subrenal capsule assay. Jpn J Surg 1986; 16: 257–261.

    PubMed  CAS  Article  Google Scholar 

  6. Hairabayashi N, Nosoh Y, Niimi K, Nishiyama M, Yamaguchi M, Toge T, Niimoto M, Hattori T. Comparative studies onin vitro human tumor clonogenic assay (HTCA) andin vivo nude mouseisotope assay (NM-IA). Jpn J Surg 1987; 17: 104–109.

    Article  Google Scholar 

  7. Von Hoff DD, Casper J, Bradley E, Standbach J, Jones D, Mukuch R. Association between human tumor colony-forming assay results and response of an individual patient’s tumor to chemotherapy. Am J Med 1981; 70: 1027–1032.

    Article  Google Scholar 

  8. Kangas L, Gronroos M, Nieminen AL. Bioluminescence of cellular ATP; a new method for evaluating cytotoxic agentsin vitro. Medical Biology 1984; 62: 338–343.

    PubMed  CAS  Google Scholar 

  9. Koyama Y. Criteria of Japan Society for Cancer Therapy. Nihonganchiryogakkaishi (Jpn J Cancer Therapy) 1986; 13: 391–396 (in Japanese)

    Google Scholar 

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Affiliations

  1. Department of Surgery, Research Institute for Nuclear Medicine and Biology, Hiroshima University, 1-2-3 Kasumi-cho, Minami-ku, 734, Hiroshima, Japan

    Masahiko Nishiyama MD, Shinichi Takagami, Yoshimasa Kirihara, Toshiaki Saeki, Ken Niimi, Yoshihiro Nosoh, Naoki Hirabayashi, Minoru Niimoto & Takao Hattori

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  1. Masahiko Nishiyama MD
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  2. Shinichi Takagami
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  3. Yoshimasa Kirihara
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  4. Toshiaki Saeki
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  5. Ken Niimi
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  6. Yoshihiro Nosoh
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  7. Naoki Hirabayashi
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  8. Minoru Niimoto
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  9. Takao Hattori
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Nishiyama, M., Takagami, S., Kirihara, Y. et al. The indications of chemosensitivity tests against various anticancer agents. The Japanese Journal of Surgery 18, 647–652 (1988). https://doi.org/10.1007/BF02471525

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  • DOI: https://doi.org/10.1007/BF02471525

Key Words

  • chemosensitivity test
  • nude mouse isotope assay
  • subrenal capsule assay
  • human tumor clonogenic assay
  • ATP assay