Abstract
LDH isozymes in both the serum and tumor tissues of 4 patients with mediastinal yolk sac tumors, and in the cystic content of tumors transplanted into nude mice was examined. Our findings suggested that LDH-1, along with AFP, is an important marker of this tumor, and that LDH isozyme study is necessary for its diagnosis.
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Zontag HA. Enzyme activity in dysgerminoma and seminoma: A study of lactate dehydrogenase isozymes in malignant disease. Rhode Island Med J 1964; 47: 273–278.
Zontag HA, Klein F. Clinical applications of lactate dehydrogenase isozymes: Alterations in malignancy. Ann NY Acad Sci 1968; 151: 578–586.
Lippert M, Papadopoulos N, Jadpour N. Role of lactate dehydrogenase isoenzymes in testicular cancer. Urology 1981; 18: 50–53.
Liu F, Fritche HA, Trujillo J, Samuels ML. Serum lactate dehydrogenase isoenzyme-1 in patient with advanced testicular cancer. Am J Clin Pathol 1982; 78: 178–183.
Sheiko MC, Hart WR. Ovarian germinoma (dysgerminoma) with elevated serum lactic dehydrogenase: Case report and review of literature. Cancer 1982; 49: 994–998.
Kumaki H, Takeuchi H, Nakamura K, Ohmi K, Bessho F, Kobayashi N. Serum lactate dehydrogenase-1 in children with yolk sac tumor. Cancer 1985; 56: 178–181.
Wroblewski F, La-Due JS. Lactic dehydrogenase activity in blood. Proc Soc Exp Biol Med 1955; 90: 210–213.
Cahn RD, Kaplan NO, Levine I, Zwilling E. The nature and development of lactic dehydrogenases. The two major types of this enzyme form molecular hybrids which change in make up during development. Science 1962; 136: 962–969.
Markert CL. Lactate dehydrogenase isoenzymes: dissociation and recombination of subunits. Science 1963; 140: 1329–1330.
Kaplan NO. Lactate dehydrogenase—Structure and function. Brookhaven Symp Biol 1964; 17: 131–153.
Goldman RD, Kaplan NO, Hall TC. Lactic dehydrogenase in human neoplastic tissues. Cacer Res 1964; 24: 384–399.
Wieland T, Pfleider G. Chemical differences between multiple forms of lactic acid dehydrogenase. Ann NY Acad Sci 1961; 94: 691–701.
Oliver JA, ElHilai MM, Belitzky P, MacKinnon KJ. The LDH-isoenzymes in benign and malignant prostatic tissue. The LDH-V/I ratio is an index of malignancy. Cancer 1970; 25: 863–866.
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Ito, M., Taki, T., Mitsuoka, A. et al. Lactate dehydrogenase isoenzyme-1 in the mediastinal yolk sac tumor. The Japanese Journal of Surgery 18, 419–422 (1988). https://doi.org/10.1007/BF02471467
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DOI: https://doi.org/10.1007/BF02471467