Abstract
A 39-year-old Japanese man with a splenic hamartoma who underwent surgery, is reported herein. The patient had a volvulus of the transverse colon and acute Type A hepatitis. His symptoms included fever, abdominal pain and icterus and the serum chemistry showed liver dysfunction and an elevation of hepatitis A antibody levels. Barium enema revealed a volvulus of the transverse colon. Ultrasonogram showed a hypoechoic mass and angiogram showed evidence of stretching of the intrasplenic vessels in the arterial phase and a hypovascular mass lesion in the venous phase. Macroscopically, the tumor was a well-defined, whitishyellow, hard nodule. Microscopically, the tumor was composed of fibrous scar tissue containing scattered red pulp tissues and the histologic diagnosis was a splenic hamartoma of the fibrous type. The patient’s postoperative recovery was uneventful. The clinical features of splenic hamartoma are reviewed in this report and the differential diagnosis is also discussed.
Similar content being viewed by others
References
Silverman ML, LiVolsi VA. Splenic hamartoma. Am J Clin Pathol 1978; 70: 224–229.
Morgenstern L, McCafferty L, Rosenberg J, Michel SL. Hamartomas of the spleen. Arch Surg 1984; 119: 1291–1293.
Hisano S, Sumiyoshi A, Tanaka K. Splenic hamartoblastoma. Jap J Cancer Clin 1973; 19: 1193–1198.
Saku M, Okudaira T, Kiyose T, Ogawa Y, You S, Kobayashi T, Inoguchi K. Splenic hamartoma. Report of a case. Geka Sinryou 1973; 15: 154–158. (in Japanese)
Kishikawa T, Numaguchi Y, Watanabe K, Matsuura K. Angiographic diagnosis of benign and malignant splenic tumors. Am J Roentgenol 1978; 130: 339–344.
Ohta M, Tsutsumi Y, Tanaka Y. Splenic hamartoma. Acta Pathol Jpn 1986; 36: 471–480.
Mordasini E. Über Splenome (Hamartome) der Miltz. Virchows Arch J Pathol Anat 1937; 298: 594–615.
Sweet RH, Warren S. Hamartoma of the spleen. Report of a case. N Eng J Med 1942; 226: 757–759.
Kirkland WG, McDonald JR. Hamartoma of the spleen. Report of three surgical cases. Arch Pathol 1948; 45: 371–379.
Coe JI, Von Drashek SC. Hamartoma of the spleen. A report of four cases. Am J Pathol 1952; 28: 663–667.
Videbaek AGE. Hypersplenism associated with hamartomas of the spleen. Acta Med Scandinav 1953; 146: 276–280.
Schrijver H, Verdonk GJ. Hamartoma of the spleen with inhibition of the bone marrow. Acta Med Scandinav 1957; 158: 235–237.
Wallach JB, Nakao K. Hamartoma of the spleen. J Med Soc N J 1962; 59: 75–79.
Sen Gupta PC, Mukerjee AM. Hamartoma of the spleen. J Indian M A 1963; 41: 610.
Wexler L, Abrams HL. Hamartoma of the spleen. Angiographic observations. Am J Roentgenol Rad Therapy Nuclear Med 1964; 92: 1150–1155.
Berge TH. Splenoma. Acta Pathol et Microbiol Scandinav 1965; 63: 333–339.
Rösch J. Tumours of the spleen: The value of selective arteriography. Clin Radiol 1966; 17: 183–190.
Van Heerden JA, Longo MF, Cardoza F, Farrow GM. The abdominal mass in the patient with tuberous sclerosis. Arch Surg 1967; 95: 317–319.
Ross CF, Schiller KFR. Hamartoma of spleen associated with thrombocytopenia. J Pathol 1971; 105: 62–64.
Teates CD, Seale DL, Allen MS. Hamartoma of the spleen. Am J Roentgenol Radium Ther Nucl Med 1972; 116: 419–422.
Darden JW, Teeslink R, Parrish RA. Hamartoma of the spleen. A manifestation of tuberous sclerosis. Am Surg 1975; 41: 564–566.
Bhagwat AG, Datta DV, Mitra S, Aikat BK. Splenoma with portal hypertension. Br Med J 1975; 3: 520.
Komaki S, Gombas OF. Angiographic demonstration of a calcified splenic hamartoma. Radiol 1976; 121: 77–78.
Kuykendall JD, Shanser JD, Sumner TE, Goodman LR. Multimodal approach to diagnosis of hamartoma of the spleen. Pediat Radiol 1977; 5: 239–241.
Shalev O, Ariel I. Hamartoma of the spleen. A case report. Israel J Med Sci 1978; 14: 862–864.
Iozzo RV, Haas JE, Chard RL. Symptomatic splenic hamartoma: A report of two cases and review of the literature. Pediatrics 1980; 66: 261–265.
Spalding RM, Jennings CV, Yam LT. Splenic hamartoma. Br J Radiol 1980; 53: 1197–1200.
Halevy A, Adam YG, Reif R, Kaufman S. Hamartoma of the spleen associated with thrombocytopenia mimicking gastric tumor. Int Surg 1982; 67: 462–463.
Pardo-Mindan FJ, Vazquez JJ, Joly M, Rocha E. Splenic hamartoma, vascular type, with endothelial proliferation. Pathol Res Pract 1983; 177: 32–40.
Rappaport H. Tumors of the hematopoietic system. In Atlas of Tumor Pathology, Section III. Fascicle 8, Armed Forces Institutes of Pathology, Washington, DC, 1966.
Butler JJ. Pathology of the spleen in benign and malignant conditions. Histopathology 1983; 7: 453–474.
Morgenstern L, Rosenberg J, Geller SA. Tumors of the spleen. World J Surg 1985; 9: 468–476.
Piekarski J, Federie MP, Moss AA, London SS. Computed tomography of the spleen. Radiology 1980; 135: 683–689.