Abstract
Left lung autotransplantation was performed in mongrel dogs to examine the limitation of tolerance of the deflated lung against warm ischemia in a warm ischemic time (WIT) range of 60–360 minutes. The animals were divided into the 4 following groups according to the duration of WIT and the use of heparin: Group 1; WIT 60–120 min., heparin (−), Group 2; WIT 120–240 min., heparin (+), Group 3; WIT 240–360 min., heparin (+), and Group 4; WIT 240–360 min., heparin (−). All the Group 1 animals tolerated a right pulmonary artery ligation on the 6th postoperative day, but some of the Group 2 animals died immediately after the reimplantation due to pulmonary edema. All the Groups 3 and 4 animals died. The PaO2 values during the right pulmonary artery occlusion, immediately after the reimplantation, correlated well with the survival of the animals. The maximum tolerable WIT of the deflated dog lung was considered to be 120 minutes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Blades B, Pierpont HC, Samadi A, Hill RP. The effect of experimental lung ischemia on pulmonary function—a preliminary report. Surg Forum 1953; 4: 255–260.
Kondo Y, Turner MD, Cockrell JV, Hardy JD. Ischemic tolerance of the canine autotransplantated lung. Surgery 1974; 76: 447–453.
Hankinson HW, Edwards FR. The effect of pulmonary ischemia on lung function. Thorax 1959; 14: 122–124.
Fonkalsrud EW, Higashijima I, Sarwat AK, Arima E, Sanchez M. Evaluation of pulmonary function in the ischemic, nonventilated canine lung. Surgery 1974; 76: 527–532.
Vieth FJ, Sinha SBP, Graves JS, Boley SJ, Dougherty JC. Ischemic tolerance of the lung—the effect of ventilation and inflation. J Thorac Cardiovasc Surg 1971; 61: 804–810.
Stevens GH, Rangel DM, Yakeishi Y, Sanchez MM, Fonkalsrud EW. The relationship of ventilation to preservation of the ischemic canine lung graft. Curr Top Surg Res 1969; 1: 51–66.
Fonkalsrud EW, Sanchez M, Lassaletta L, Smeesters C, Higashijima I. Extended preservation of the ischemic canine lung by ventilation with PEEP. J Surg Res 1975; 18: 437–445.
Haverich A, Scott WC, Jamieson SW. Twenty years of lung preservation—a review. Heart Transplant 1985; 4: 234–240.
Vieth FJ, Richards K. Improved technique for canine lung transplantation. Ann Surg 1970; 717: 553–558.
Siegelman SS, Sinha SBP, Vieth FJ. Pulmonary reimplantation response. Ann Surg 1973; 177: 30–36.
The Toronto Lung Transplant Group. Sequential bilateral lung transplantation for paraquat poisoning. J Thorac Cardiovasc Surg 1985; 89: 734–742.
Benfield JR, Beall GN, Gondos B, Peter ME, Shimada K, Schick P. Serial observation on immunologically matched lung allografts. J Thorac Cardiovasc Surg 1972; 64: 904–921.
Vieth FJ, Torres M, Koerner S, Buchberg A, Gliedman ML. Functional adequacy of transplanted lungs in the early postoperative period: definition and extension of tolerable ischemia. Transplant Proc 1969; 1: 325–327.
Fujimura S, Parmley WW, Tomoda H, Norman JR, Matloff JM. Hemodynamic alterations after staged and simultaneous bilateral lung autotransplantation in dogs—immediate studies. J Thorac Cardiovasc Surg 1972; 63: 527–533.
Garzon AA, Cheng C, Pangan J, Karlson KE. Hypothermic hyperbaric lung preservation for twenty-four hours with reimplantation. J Thorac Cardiovasc Surg 1968; 55: 546–554.
Arnar O, Andersen RC, Hitchcock CR, Haglin JJ. Reimplantation of the baboon lung after extended ischemia. Transplant 1967; 5: 929–935.
Handa M. Lung preservation under continuous low flow perfusion for 6 and 12 hours. Kokenshi 1982; 34: 72–85.
Toledo-Pereyra LH, Hau T, Simmons RL, Najarian JS: Lung preservation techniques. Ann Thorac Surg 1977; 23: 487–494.
Hoyer J, Garbe L, Delpierre S, Prieur A, Macquart-Moulin G, Noirclerc M. Functional evaluation of the transplanted lung after long-term preservation. Respiration 1980; 39: 323–332.
Nelems JM, Duffin J, Glynn MFX, Brebner J, Scott AA, Cooper JD. Extracorporeal membrane oxygenator support for human lung transplantation. J Thorac Cardiovasc Surg 1978; 76: 28–31.
Gattinoni L, Agostoni A, Pesenti A, Pelizzola A, Rossi GP, Langer M, Vesconi S, Uziel L, Fox U, Longoni F, Kolobow T, Damia G: Treatment of acute respiratory failure with low-frequency positive-pressure ventilation and extracorporeal removal of PO2. Lancet 1980; 292–294.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yamazaki, F., Wada, H., Aoki, M. et al. An evaluation of the tolerance of the autotransplanted canine lung against warm ischemia. The Japanese Journal of Surgery 19, 326–333 (1989). https://doi.org/10.1007/BF02471409
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02471409