Skip to main content
SpringerLink
Log in

The histological effects of cryocoagulation on the myocardium and coronary arteries

  • Original Articles
  • Published:
The Japanese journal of surgery Aims and scope Submit manuscript

Abstract

The effects of epicardial and endocardial cryolesions were histologically studied in 29 dogs. To produce epicardial lesions, hypothermic exposure was applied at −60°C for 3 minutes, over or adjacent to the left anterior descending coronary artery. To produce endocardial lesions, exposure was applied at −60°C for 2 minutes, using the inflow occlusion technique over the ventricular septum. The dogs were killed 30 minutes to 6 months later. The cryolesions were sharply demarcated from the surrounding tissues and showed similar healing processes. The lesions showed no tendency to form aneurysms or rupture, although moderate intimal thickening of the coronary artery subjacent to the probe was observed. Our results indicate that cryocoagulation may greatly contribute to the surgical treatment of cardiac arrhythmias.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Harrison L, Gallagher JJ, Kasell J, Anderson RW, Mikat E, Hackel DB, Wallace AG. Cryosurgical ablation of A-V node-His bundle: a new method for producing A-V block. Circulation 1977; 55: 463–470.

    PubMed  CAS  Google Scholar 

  2. Gallagher JJ, Sealy WC, Anderson RW, Kasell J, Millar R, Campbell RWF, Harrison L, Pritchett ELC, Wallace AG. Cryosurgical ablation of accessory atrioventricular connection. Circulation 1977; 55: 471–479.

    PubMed  CAS  Google Scholar 

  3. Gallagher JJ, Anderson RW, Kasell J, Rice JR, Pritchett ELC, Gault JH, Harrison L, Wallace AG. Cryoablation of drug-resistant ventricular tachycardia in a patient with a variant of scleroderma. Circulation 1978; 57: 190–197.

    PubMed  CAS  Google Scholar 

  4. Camm J, Ward DE, Spurrell RAJ, Ress GM. Cryothermal mapping and cryoablation in the treatment of refractory cardiac arrhythmias. Circulation 1980; 62: 67–74.

    PubMed  CAS  Google Scholar 

  5. Iwa T, Kobayashi H, Sato H, Mukai K, Hirano M, Tsuchiya K, Naganuma M, Koike K. Successful surgical treatment of idiopathic ventricular tachycardia. Shinzo 1981; 13: 478–484. (in Japanese)

    Google Scholar 

  6. Hass GM, Taylor CB. A quantitative hypothermal method for the production of local injury of tissue. Arch Pathol 1948; 45: 563–580.

    Google Scholar 

  7. Taylor CB, Davis CB, Vawter GF, Hass GM. Controlled myocardial injury produced by a hypothermal method. Circulation 1951; 3: 239–253.

    PubMed  CAS  Google Scholar 

  8. Gallagher JJ. Surgical treatment of arrhythmias: Current status and future directions. Am J Cardiol 1978; 41: 1035–1044.

    Article  PubMed  CAS  Google Scholar 

  9. Mazur P. Physical-chemical factors underlying cell injury in cryosurgical freezing. In: Rand RW, Rinfret PR, von Leden H, eds, Cryosurgery. Springfield: Charles C Thomas, 1968; 32–51.

    Google Scholar 

  10. Mikat EM, Hackel DB, Harrison L, Gallagher JJ, Wallace AG. Reaction of the myocardium and coronary arteries to cryosurgery. Lab Invest 1977; 37: 632–641.

    PubMed  CAS  Google Scholar 

  11. Misaki T, Allwork SP, Bentall HH. The longterm effects of cryosurgery in the sheep heart. Cardiovasc Res 1983; 17: 61–69.

    Article  PubMed  CAS  Google Scholar 

  12. Ohkawa S, Hackel DB, Mikat EM, Gallagher JJ, Cox JL, Sealy WC. Anatomic effects of cryoablation of the atrioventricular conduction system. Circulation 1982; 65: 1155–1162.

    PubMed  CAS  Google Scholar 

  13. Klein GJ, Harrison L, Ideker RF, Smith WM, Kasell J, Wallace AG, Gallagher JJ. Reaction of the myocardium to cryosurgery: electrophysiology and arrhythmogenic potential. Circulation 1979; 59: 364–372.

    PubMed  CAS  Google Scholar 

  14. Iwa T, Misaki T, Kamata E, Mitsui T, Hashizume Y, Kawasuji M. Surgical experiences of non-ischemic ventricular tachycardia. Jpn Ann Thor Surg 1983; 3: 31–38. (in Japanese)

    CAS  Google Scholar 

  15. Misaki T, Iwa T, Mukai K, Watanabe G, Matsunaga Y, Tsubota M, Kuzawa Y, Shinagawa M. Surgical treatment for nonischemic ventricular tachycardia arising from left ventricular apex. J Jpn Assoc Thor Surg 1988; 36: 1245–1249. (in Japanese)

    CAS  Google Scholar 

  16. Misaki T, Mukai K, Tsubota M, Ueyama K, Watanabe G, Matsunaga Y, Iida S, Iwa T. Surgical treatment for nonischemic ventricular tachycardia arising from left posterior ventricular septum. Cardiac Pacing 1988; 4: 393–398. (in Japanese)

    Google Scholar 

  17. Misaki T, Iida S, Iwa T. Cardiac cryocoagulation for the treatment of tachyarrhythmias. Jpn Ann Thor Surg 1988; 8: 319–321. (in Japanese)

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Department of Surgery (1), Kanazawa University School of Medicine, 13-1 Takaramachi, 920, Kanazawa, Japan

    Shigeho Iida, Takuro Misaki & Takashi Iwa MD

Authors
  1. Shigeho Iida
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takuro Misaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takashi Iwa MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Iida, S., Misaki, T. & Iwa, T. The histological effects of cryocoagulation on the myocardium and coronary arteries. The Japanese Journal of Surgery 19, 319–325 (1989). https://doi.org/10.1007/BF02471408

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02471408

Key Words

Search

Navigation