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Abnormal plasma prothrombin (PIVKA-II) levels in hepatocellular carcinoma

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Abstract

The concentration of abnormal prothrombin, or the protein induced by vitamin K absence or antagonist II (PIVKA-II) in 102 patients with hepatic disorders was measured by an enzyme immunoassay method. The concentration of PIVKA-II in the plasma was elevated in 11 out of 18 patients with hepatocellular carcinoma and also in a patient with hepatoblastoma. There was no correlation between serum α-fetoprotein and plasma PIVKA-II levels. The PIVKA-II level was normal in 11 patients who had metastatic carcinoma or cholangiocellular carcinoma. Moreover, benign diseases of the liver did not cause an elevation in PIVKA-II. PIVKA-II might be an useful marker of hepatocellular carcinoma because, like α-fetoprotein, its level changes in close relation to the effects of treatment.

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  1. The Department of Surgery, Kansai Medical University, 1 Fumizono, Moriguchi, 570, Osaka, Japan

    Yusai Kawaguchi MD

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  1. Yusai Kawaguchi MD
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Kawaguchi, Y. Abnormal plasma prothrombin (PIVKA-II) levels in hepatocellular carcinoma. The Japanese Journal of Surgery 19, 296–300 (1989). https://doi.org/10.1007/BF02471405

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  • DOI: https://doi.org/10.1007/BF02471405

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