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Malignant fibrous histiocytoma in the thoracic region —A clinico-pathologic investigation

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Abstract

Seven cases of malignant fibrous histiocytoma (MFH); 3 originating in the thoracic region, one which was considered to arise from the lung parenchyma, and 4 which were metastatic to the lungs, are presented herein. Six of these patients underwent surgical excision and analysis under light and electron microscopy revealed the lesions of MFH to be composed of two cell types; a fibroblast-like cell and a histiocyte-like cell. The latter showed histologically characteristic growth in a so-called storiform pattern. In all patients adjuvant chemotherapy was performed, although in only one patient did it prove temporarily effective. Despite the fact that the prognosis of MFH in the thoracic region is poor, the suggested therapy for longer survival is resection with postoperative combination chemotherapy including the use of sensitive anticancerous agents.

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Authors and Affiliations

  1. The Second Department of Surgery, School of Medicine, Fukuoka University, 45-1 Nanakuma, 814-01, Fukuoka, Japan

    Takayuki Shirakusa MD

  2. The First Department of Pathology, School of Medicine, Fukuoka University, 45-1 Nanakuma, 814-01, Fukuoka, Japan

    Koei Ando & Takuo Kusano

  3. The Department of Orthopaedics, School of Medicine, Fukuoka University, 45-1 Nanakuma, 814-01, Fukuoka, Japan

    Sansen Yoh

Authors
  1. Takayuki Shirakusa MD
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  2. Koei Ando
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  3. Takuo Kusano
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  4. Sansen Yoh
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Shirakusa, T., Ando, K., Kusano, T. et al. Malignant fibrous histiocytoma in the thoracic region —A clinico-pathologic investigation. The Japanese Journal of Surgery 19, 283–289 (1989). https://doi.org/10.1007/BF02471403

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