The Japanese journal of surgery

, Volume 16, Issue 2, pp 106–111 | Cite as

Carcinoembryonic antigen slope analysis as an early indicator for recurrence of colorectal carcinoma

  • Osamu Kimura
  • Nobuaki Kaibara
  • Hideaki Nishidoi
  • Tsuneyuki Okamoto
  • Masataka Takebayashi
  • Hiroki Kawasumi
  • Shigemasa Koga
Original Articles

Abstract

We analyzed the time course of postoperative serum CEA concentrations in 229 patients with histologically confirmed colorectal carcinoma. Preoperative CEA levels were correlated with Dukes' stages, however, the preoperative CEA value was of limited value as a screening procedure. In 42 patients with tumor recurrence after radical resection, a diagnosis of relapse, based on a rise in the CEA concentration, preceded the positive clinical symptoms. Analysis of the CEA time course made it possible to differentiate local tumor recurrence and generalized metastasis, regardless of the histologic type or primary site of the tumor.

Key Words

CEA slope analysis recurrence colorectal carcinoma 

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References

  1. 1.
    Gold P, Freedman SO. Demonstration of tumor specific antigen in human colonic carcinoma by immunological tolerance and absorption techniques. J Exp Med 1965; 121: 439–462.PubMedCrossRefGoogle Scholar
  2. 2.
    Kato K, Morimoto T, Kato T, Yasue M, Takagi H, Kito T, Nakazato H, Miyaishi S, Yamada E, Kuwabara M, Suchi T. CEA assays in postoperative detection of recurrent colorectal carcinoma. Nippon Ganchiryo Gakkai Zasshi (J Jpn Soc Cancer Ther) 1980; 15: 1137–1142. (English Abst.)Google Scholar
  3. 3.
    Martin EW, James KK, Hurtubise PE, Catalano P, Minton JP. The use of CEA as an early indicator for gastrointestinal tumor recurrence and second-look procedures. Cancer 1977; 39: 440–446.PubMedCrossRefGoogle Scholar
  4. 4.
    Staab HJ, Anderer FA, Stumpf E, Fischer R. Postoperative differentiation of local tumor recurrence and generalized metastasizing in patients with adenocarcinomas of the digestive system by CEA follow-up study. Scand J Immunol 1978; 8: 459–464.CrossRefGoogle Scholar
  5. 5.
    Staab HJ, Anderer FA, Stumpf E, Fischer R. Slope analysis of the postoperative CEA time course and its possible application as an aid in diagnosis of disease progression in gastrointestinal cancer. Am J Surg 1978; 136: 322–327.PubMedCrossRefGoogle Scholar
  6. 6.
    Staab HJ, Anderer FA, Stumpf E, Fischer R. Carcinoembryonic antigen follow-up and selection of patients for second-look operation in management of gastrointestinal carcinoma. J Surg Oncol 1978; 10: 273–282.PubMedGoogle Scholar
  7. 7.
    Sasaki T, Maruyama M, Funada A, Sugiyama N, Takekoshi T, Baba Y, Ninomiya K, Narii T, Takagi K, Takahashi T, Hori M, Nakamura K, Futsukawa M. Plasma CEA levels of cancer of colon and rectum. I to Cho (Stomach and Intestine) 1977; 12: 253–261. (English Abst.)Google Scholar
  8. 8.
    Moore T, Dhar P, Zamcheck N, Keeley A, Gottlieb L, Kupchik HZ. Carcinoembryonic antigen(s) in liver disease I. Clinical and morphological studies. Gastroenterology 1972; 63: 88–94.PubMedGoogle Scholar
  9. 9.
    Lurie BB, Loewenstein MS, Zamcheck N. Elevated carcinoembryonic antigen levels and biliary tract obstruction. JAMA 1975; 233: 326–330.PubMedCrossRefGoogle Scholar

Copyright information

© The Japan Surgical Society 1986

Authors and Affiliations

  • Osamu Kimura
    • 1
  • Nobuaki Kaibara
    • 1
  • Hideaki Nishidoi
    • 1
  • Tsuneyuki Okamoto
    • 1
  • Masataka Takebayashi
    • 1
  • Hiroki Kawasumi
    • 1
  • Shigemasa Koga
    • 1
  1. 1.The First Department of SurgeryTottori University School of MedicineYonagoJapan

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