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The Japanese journal of surgery

, Volume 21, Issue 5, pp 590–593 | Cite as

Clinical significance of P-glycoprotein expression analyzed by immunohistochemical staining in cancer tissues

  • Ryungsa Kim
  • Naoki Hirabayashi
  • Masahiko Nishiyama
  • Kenjiro Aogi
  • Tetsuya Toge
Short Communications
  • 22 Downloads

Abstract

P-glycoprotein is a transmembrane protein with increased drug efflux from resistant cells, which is encoded by the MDR1 gene. An overexpression of P-glycoprotein has been reported to correlate with the degree of resistance to anticancer agents, especially to adriamycin. In this study, the expression of P-glycoprotein was analyzed immunohistochemically by using a monoclonal antibody, MRK16 against P-glycoprotein in 18 fresh human tumors. The expression of P-glycoprotein was detected in eight (44 per cent) tumor specimens out of 18 patients. Although six (75.0 per cent) of the 8 P-glycoprotein positive tumors were resistant to adriamycin, the other two tumors showed clinical responses. Furthermore, five (50.0 per cent) of the 10 P-glycoprotein negative tumors exhibited positive clinical responses. These results suggest that P-glycoprotein expression may not be a useful marker to predict intrinsic resistance to adriamycin in fresh human tumors.

Key Words

P-glycoprotein monoclonal antibody adriamycin resistance multidrug resistance 

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Copyright information

© The Japan Surgical Society 1991

Authors and Affiliations

  • Ryungsa Kim
    • 1
  • Naoki Hirabayashi
    • 1
  • Masahiko Nishiyama
    • 1
  • Kenjiro Aogi
    • 1
  • Tetsuya Toge
    • 1
  1. 1.The Department of Surgery, Research Institute for Nuclear Medicine and BiologyHiroshima UniversityHiroshimaJapan

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