Abstract
In the present study, we investigated how the recent clinical use of antibiotics have altered the antibiotic susceptibility of strains isolated from postoperative infections, especially Gram-negative rods. ForPseudomonas aeruginosa, serogroup E strains acounted for about 20 per cent of postoperative infections, but were unable to the isolated from either the feces of patients on admission or from the appendix contents of patients with appendicitis. It therefore appeared that serogroup E strains were responsible for the nosocomial infections in our department. The strains of methicillin-resistantStaphylococcus aureus andPseudomonas aeruginosa serogroup E, which we assumed to be nosocomial pathogens, acquired a high level of resistance to antibiotics soon after third-generation cephems became widely used. On the other hand, the antibiotic susceptibility ofEnterobacter cloacae, Citrobacter freundii, and the serogroups ofPseudomonas aeruginosa other than E, which were considered to originate from the bacterial flora of patients, did not vary throughout the several years of the study period.
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References
Takesue Y, Yokoyama T, Kodama T, Fujimoto M, Sewake H, Murakami Y, Imamura Y, Tsumura H. Methicillin-resistantStaphylococcus aureus in nosocomial infections in the surgical ward and operation room. Hiroshima J Med Sci 1989; 38: 183–186.
Yokota T. Methicillin and cephems-resistantStaphylococcus aureus. Infect. Inflammation Immun 1984; 4: 87–97. (in Japanese)
Hujii Y. On the renewal of the standard method for MIC measurement. Chemotherapy 1981; 29: 76–79. (in Japanese with English Abst.)
Homma JT. A new antigenic schema and live cell slide agglutination procedure for the infra-sub-specific serogic classification ofPseudomonas aeruginosa— Report of the Serotyping Committee of the JapanPseudomonas aeruginosa Society. Japan J Exp Med 1976; 46: 329–336.
Terada Y, Sugiyama J. Proposal for the addition of a new serogroup N in the serological classification ofPseudomonas aeruginosa. Japan J Exp Med 1982; 52: 315–316.
Takesue Y, Yokoyama T, Kodama T, Fujimoto M, Okita M, Sewake H, Murakami Y, Imamura Y, Miyamoto K, Tsumura H. A study ofPseudomonas aeruginosa in nosocomial infections in the surgical ward by serological classification. Nippon Rinsho Geka Igakkai Zasshi (J Jpn Soc Clin Surg) 1990; 51: 1623–1627. (in Japanese with English Abst.)
Preheim LC, Penn RB, Sanders CC, Goering RV, Giger DK. Emergence of resistance to β-lactam aminoglycoside antibiotics during moxalactam therapy ofP. Pseudomonas aeruginosa infections. Antimicrob Agents Chemother 1982; 22: 1037–1041.
Sanders CC, Sander WEJ. Emergence of resistance during therapy with the newer β-lactamases and implications for the future. Rev Infect Dis 1983; 5: 639–648.
Jacoby GA, Sutton L. β-lactamases and β-lactam resistance inEscherichia coli. Antimicrob Agents Chemother 1985; 28: 703–705.
Sanders CC. Novel resistance selected by the new expanded-spectrum cephalosporins. J Infect Dis 1983; 147: 585–589.
Vu H, Nikaido H. Role of β-lactam hydrolysis in the mechanism of resistance of a β-lactamase-constitutiveEnterobacter cloacae strain to expanded spectrum β-lactams. Antimicrob Agents Chemother 1985; 27: 393–398.
Matsuhashi M, Song MD, Ishino F, Wachi M, Doi M, Inoue M, Ubukata K, Yamashita N, Konno M. Moleclar cloning of the gene of a penicillin-binding protein supposed to cause high resistance to β-lactam antibiotics inStaphylococcus aureus. J Bacteriol 1986; 167: 975–980.
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Takesue, Y., Yokoyama, T., Kodama, T. et al. The influence of clinical use of antibiotics on the sensitivity of strains isolated from postoperative infections —A comparison of nosocomial pathogens with strains isolated from the bacterial flora of patients—. The Japanese Journal of Surgery 21, 376–380 (1991). https://doi.org/10.1007/BF02470964
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DOI: https://doi.org/10.1007/BF02470964