Abstract
Two cases of ulcerative colitis with a positive Coombs test are reported herein. In a 30 year old woman, hemolytic anemia was well controlled by excision of a rectal stump left over from a former operation. A 53 year old woman had a positive Coombs test without clinical hemolytic anemia 10 years after undergoing a total procto-colectomy with ileo-anal anastomosis. Thus we concluded that total procto-colectomy may be preventive, as well as therapeutic, for Coombs positive hemolytic anemia associated with ulcerative colitis.
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References
Edwards GG, Truelove SC. The course and prognosis of ulcerative colitis. Part III. Complications. Gut 1964; 5: 1–22.
Gumaste V, Greenstein AJ, Meyers R, Sacher DV. Coombs-positive autoimmune hemolytic anemia in ulcerative colitis. Dig Dis Sci 1989; 34: 1457–1461.
Goodacre RL, Ali M, Vanderlinden B, Hamilton J, Castelli M, Seaton T. Hemolytic anemia in patients receiving sulfasalazine. Digestion 1978; 17: 503–508.
Lehtenen M, Lehtenen E, Nikkila EA. Microangiopathic hemolytic anemia in ulcerative colitis. Scan J Gastroenterol 1968; 3: 417–424.
Lang S, Weber D. Die autoimmunhaemolitishe Anaemie bei Colitis Ulcerosa. Schweiz med Wschr 1985; 115: 897–902.
Jacob J, Lance KP. Antibody coated red cell-with and without hemolysis in chronic ulcerative colitis. Am J Gastroenterol 1976; 65: 324–328.
Mechanick JI. Coomb's positive hemolytic anemia following sulfasalazine therapy in ulcerative colitis; Case reports, review, and discussion of pathogenesis. Mount Sinai J Med 1985; 52: 667–670.
Basista MH, Roe DC. A case presentation of hemolytic anemia in ulcerative colitis and review of the literature. Am J Gastroenterol 1986; 81: 990–992.
Wodzinski MA, Lawrence ACK. Severe Coombs positive autoimmune hemolytic anemia associated with ulcerative colitis. Postgrad Med J 1985; 61: 261–262.
Shikai T, Shima K, Tsuda T, Higuchi S, Watanabe H, Takenaka T. A case of autoimmune hemolytic anemia with ulcerative colitis and subacute myelooptico-neuropathy. Rinsho Meneki (Clin Immunol) 1972; 4: 1293–1298. (in Japanese)
Goldstone AH. Autoimmune hemolytic anemia in ulcerative colitis. Br Med J 1974; 2: 556.
Balint JA, Hammack WJ, Patton TB. Association of ulcerative colitis and red blood cells coated with autoimmune antibody. Report of a case. Am J Dig Dis 1963; 8: 537–544.
Chiba M, Nakajima K, Arakawa H, Masamune O, Narisawa T. Anti-erythrocyte antibodies in ulcerative colitis: Case report and discussion on the pathophysiology of anti-erythrocyte antibody. Gastroenterol Jpn 1988; 23: 564–569.
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Iwama, T., Imajo, M. & Mishima, Y. Coombs-positive autoimmune hemolytic anemia in ulcerative colitis —A report of two cases—. The Japanese Journal of Surgery 21, 341–343 (1991). https://doi.org/10.1007/BF02470957
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DOI: https://doi.org/10.1007/BF02470957