Skip to main content
SpringerLink
Log in

A case of calcifying carcinoma of the stomach with long-term postoperative survival

  • Case Reports
  • Published:
The Japanese journal of surgery Aims and scope Submit manuscript

Abstract

A 28 year old man suffering from calcifying carcinoma of the stomach underwent a gastrectomy which was histologically classified as being a noncurative resection. As postoperative adjuvant chemotherapy, he received 116 mg of Mitomycin C and 454.8 g of Tegafur as well as 5690 g of ascorbic acid. He showed carcinoma cells histologically at both oral and anal edges of the resected specimen, and peritoneal metastases of tumor cells were also observed, but he nevertheless kept a performance status of 1 until 5 years after surgery. The patient finally died of cachexia 5 years and 6 months after his operation. Among 42 patients with calcifying carcinoma of the stomach reported in the foreign literature and 19 patients reported in Japanese, those patients for whom the postoperative survival time was clearly indicated did not necessarily survive longer than those patients without calcification.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Imbert R. Linite et calcification gastrique. Bull et mém Soc Radiol méd France 1931; 19: 351.

    Google Scholar 

  2. Beliczay PM. Calcification of gastric wall. Magy Roentgen Koel 1937; 11: 145–147 (cited by Batlan LE)

    Google Scholar 

  3. Abel W. Zur Diagnose des Magenwandverkalkungen. Fortschr Roentgenstr 1939; 59: 57–64.

    Google Scholar 

  4. Riedel Ol Cancer calcificado de estomago. Rev méd Chile 1940; 68: 334. (cited by Batlan LE)

    Google Scholar 

  5. Tenconi E. Calcification del cancer de estomago. Radiologia 1944; 7: 113–117.

    Google Scholar 

  6. Robertson JW, Osterhout S. Calcification in scirrhous carcinoma of the stomach. Am J Surg 1952; 83: 830–832.

    Article  PubMed  CAS  Google Scholar 

  7. Batlan LE. Calcification within the stomach wall in gastric malignancy. Am J Roentgenol 1954; 72: 788–794.

    CAS  Google Scholar 

  8. Kendig TA, Gaspan MR, Secrest PG, Shackford BC. Calcification in gastric carcinoma. Radiology 1957; 68: 80–82.

    PubMed  Google Scholar 

  9. Matthews WA, Skandalakis JE, Mitchell MA, Weens HS. Calcification in gastrointestinal malignancy. Gastroenterol 1958; 34: 959–968.

    CAS  Google Scholar 

  10. Petersen O. Calcification in carcinoma of the stomach. Acta Radiol 1958; 49: 416–418.

    Article  PubMed  CAS  Google Scholar 

  11. Butler RL, Cotran R. Petrified stomach. New Engl J Med 1959; 261: 84–86.

    Article  PubMed  CAS  Google Scholar 

  12. Khilnani MT. Calcifying mucous-cell carcinoma of the stomach. Am J Dig Dis 1960; 5: 479–483.

    Article  PubMed  CAS  Google Scholar 

  13. McGinnis GO. Adenocarcinoma of the stomach with calcification. Gastroenterol 1960; 39: 90–93.

    Google Scholar 

  14. Crosta G, Salvini A. Ladenocarcinoma calcificante dello stomaco. Lóspedale Maggiore 1960; 7: 302–308.

    Google Scholar 

  15. Marc PR, Guiffant ML, Treut AL, Veyret J, Joly R. A Propos Dune Observation de Psammocarcinome du Fole. Le Diagnostic des Calcifications Intra-Hepatiques. J de Radiologie 1960; 41: 481–483.

    CAS  Google Scholar 

  16. Jacobs E. Carcinomes calcifiés de léstomac. Acta Gastroent Belg 1961; 24: 622–624.

    PubMed  CAS  Google Scholar 

  17. Родцна ИА, жданова ММ, Воротцлкцн АИ. Слизистый рак желудка с оБызвествлением. Klinicheskaia Meditsina 1961; 39: 128–129.

    Google Scholar 

  18. Hermann G, Rozin R. Calcification in gastro-intestinal carcinomata. Clinical Radiology 1963; 15: 139–141.

    Article  Google Scholar 

  19. Kitagawa M, Kimata S. Diffuse calcification in mucinous cell carcinoma of stomach. Acta Path Jap 1963; 13: 287–294.

    PubMed  CAS  Google Scholar 

  20. Verstraeten J, De Vos L. Verkalktes Magenkarzinoma. Fortschr Roentgen 1964; 100: 662–664.

    Article  CAS  Google Scholar 

  21. Gemell NI. Calcification within a gastric carcinoma. A case report. Am J Roentgenol 1964; 91: 779–783.

    CAS  Google Scholar 

  22. Berezowski A. Calcification in gastric malignancy. South African J Radiol 1965; 3: 31–32.

    Google Scholar 

  23. Yamagiwa H, Itoh K, Itoh H, Takeuchi T, Yoshimi H, Haneda Y. Calcification in mucinous cell carcinoma of the stomach. Mie Medical J 1967; 17: 47–55.

    CAS  Google Scholar 

  24. Thomas RL, Rice RP. Calcifying mucinous adenocarcinoma of the stomach. Radiology 1967; 88: 1002–1003.

    PubMed  CAS  Google Scholar 

  25. Weston TS. Calcification of the stomach. A case report. Aust Radiol 1968; 12: 223–224.

    CAS  Google Scholar 

  26. Yasuma T, Hashimoto K, Miyazawa R, Hiyama Y. Bone formation and calcification in gastric cancer—case report and review of literature. Acta Path Jap 1973; 23: 155–172.

    PubMed  CAS  Google Scholar 

  27. Bloch C, Peck HM. Calcifications in gastrointestinal malinancy—An important clue in radiologic diagnosis. Mount Sinai J Med 1971; 38: 405–416.

    CAS  Google Scholar 

  28. D'Altorio RA. Calcification in a gastric mucinous adenocarcinoma. Digestive Diseases 1973; 18: 419–422.

    Article  Google Scholar 

  29. Myo Lwin TO, Soodeen TH. A case report on calcified mucinous adenocarcinoma of the stomach. Journal De L'association Ganadienne des radiologistes 1973; 24: 370–373.

    Google Scholar 

  30. Bergeron RB, Neely HR. Demonstrable calcifications in carcinoma of the stomach. J La State Med Soc 1975; 127: 17–18.

    PubMed  CAS  Google Scholar 

  31. Katz M, Delas N, Lang F, Laval Jeanter M, Canivet J, Paino-Blanco L. Un Cas de cancer gastrique calcific. J Radid Electrol 1975; 56: 273–277.

    CAS  Google Scholar 

  32. De Carvalho JC, Francischetti EA, De Barros Filho GA, Calcified mucinous adenocarcinoma of the stomach. Am J Gastro-enterol 1978; 69: 481–484.

    Google Scholar 

  33. Murayama H, Kamio A, Imai T, Kikuchi M. Gastric carcinoma with psammomatous calcification—report of a case, with reference to calculogenesis. Cancer 1982; 49: 788–796.

    Article  PubMed  CAS  Google Scholar 

  34. Oberschulte-Beckmann D, Al-Hujaj M. Tumorbedingte Magenwandverkalkungen. Fortschr Rontgenstr 1984; 140: 221–222.

    Article  CAS  Google Scholar 

  35. Dwyer RT, Phillips RL. Radiographically visible calcification in colloid carcinoma of the stomach. Australas Radiol 1986; 30: 153–155.

    PubMed  CAS  Google Scholar 

  36. Maekawa I, Hatta M. Calcium deposit in cancer of the stomach: Report of autopsy case. Jap J Cancer Clin 1966; 12: 639–642.

    CAS  Google Scholar 

  37. Hino K, Saito Y, Shibayama Y, Abe S, Dohmae A, Shibuya T, Tada Y, Sekino S. A case of calcifying mucinous adenocarcinoma of the stomach (author's translation). Medicina 1967; 4: 271–274. (in Japanese)

    Google Scholar 

  38. Sakurai H, Yamaoka I, Arai M, Aoki M, Shikata J. A case of calcifying mucoid carcinoma of the stomach. Rinsho Geka 1973; 28: 1149–1152.

    Google Scholar 

  39. Uetake M, Fukushima N. Calcification in a gastric carcinoma (author's translation). Dohai Igaku Zasshi 1975; 9: 31–36 (in Japanese)

    Google Scholar 

  40. Takahashi S, Yamamoto M, Sasaki Y, Someya K, Ishikawa T, Shibata K, Naoe S. An autopsy case on radiographically visible calcification in carcinoma of the stomach (author's translation). Shindan to Chiryo 1979; 745–748. (in Japanese).

  41. Ikutame K, Moriya H, Nagashima T, Yokoi T, Okamura R, Seki H, Ogiwara Y, Kataba Y, Watanabe H, Ushigome S, Ogata M. Diffuse calcification in a gastric carcinoma. A case report (author's translation). Geka Rinsho 1981; 897–899. (in Japanese).

  42. Nagatomi Y, Kawamura S, Amano H, Aibe T, Harima K, Maetani N, Ariyama S, Fuji T, Kawashima M, Okazaki Y, Takemoto T. A case of gastric cancer with calcium deposit. Gastroenterological Endoscopy 1982; 24: 794–801.

    Google Scholar 

  43. Ishidate T, Kudo K, Majima H, Kuno H, Mukai J. Psammomatous calcification of a gastric carcinoma with early malignancy. A case report (author's translation). Hakodate Igakkai Zasshi 1982; 6: 122–128. (in Japanese)

    Google Scholar 

  44. Yamamoto T, Okazaki K, Moriyasu F, Shiomura T, Suzaki T, Kanematsu Y, Nakamura Y, Kobashi Y. Adenocarcinoma of the stomach containing psammomabodies. Gastroenterol Jpn 1982; 79: 876–879.

    CAS  Google Scholar 

  45. Ema Y, Hayashi S, Ichikawa K, Kobayashi F, Koike M, Nakamura T, Satake T, Yoshino J. Two cases of gastric cancer with remarkable calcium deposit. Gastroenterol Jpn 1982; 79: 1630–1633.

    CAS  Google Scholar 

  46. Hoshiyama N, Miyagawa H, Ozaki M, Takechi K, Okuda J, Ida K, Achiwa Y. Calcifying mucinous adenocarcinoma of the stomach—Case report—. Jpn J Cancer Clin 1984; 30 529–538.

    CAS  Google Scholar 

  47. Kasanami T, Hironaka T, Iguchi K, Hori K, Kurioba H, Sonoyama T, Konosu H, Nonaka M. A case report of calcified gastric cancer. Jpn J Gastroenterol Surg 1984; 17: 957–960.

    Google Scholar 

  48. Matsuki K, Nakagami K, Hirono M, Niimoto M, Hattori T. Histopathological studies on gastric carcinoma with calcification. I to Cho 1984; 19: 1261–1267.

    Google Scholar 

  49. Moriuchi Y, Shimada S, Isomoto I, Iwanaga S, Mori I, Kitamura T, Maeda T, Amagasaki Y. A case of roentgenographically detectable calcification in Borrmann type 4 carcinoma of the stomach (author's translation). Rinsho to Kenkyu 1985; 62: 2195–2198. (in Japanese)

    Google Scholar 

  50. Onodera H, Kogawa T, Itani K, Shibata T, Yamamoto M, Seto O, Fukumoto K, Kondo M, Kawa J. A case of the gastric cancer with prominent calcium deposit. Gastroenterol Jpn 1985; 82: 301–305.

    CAS  Google Scholar 

  51. Itoh S, Ohta Y, Hiromatsu A, Maruyama M, Kawano Y, Irie K. A case report of gastric endocrine cell carcinoma with psammomatous calcification. J Jpn Soc Clin Cytol 1985; 24: 507–512.

    Google Scholar 

  52. Abe M, Abe S, Kobayashi O, Asaga T, Sairenji M, Sugimasa Y, Takemiya S, Masuzawa C, Kawahara S, Ishibashi M, Motohashi H, Okamoto T, Tamura N, Okada K, Tamai S, Iimori K, Oikawa Y, Miyamoto S, Unayama S. A case of gastric cancer with remarkable calcification and a review of 31 cases in the Japanese literature. J Jpn Soc Clin Surg 1986; 47: 764–769.

    Google Scholar 

  53. Tanaka H, Asada K, Tokura K, Nakata B, Usui T, Taniura M, Taruya E, Fuyuhiro Y, Nakaue K, Yanagi Z, Takebayashi J. A case report of calcified gastric cancer. J Jpn Soc Clin Surg 1986; 47: 1055–1059.

    Google Scholar 

  54. Nakano K, Fujimoto S, Tokita H. Antitumor activity of calcium in combination with antitumor agents against Lewis lung carcinoma.In Vivo 1989; 3: 147–150.

    PubMed  CAS  Google Scholar 

  55. Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal human cancer. Proc Natl Acad Sci USA 1976; 73: 3685–3689.

    Article  PubMed  CAS  Google Scholar 

  56. Bussey HJR, Decosse JJ, Deschner EE, Eyers AA, Lesser ML, Morson BC, Ritchie SM, Thomson JPS, Wadsworth J. A randomized trial of ascorbic acid in polyposis coli. Cancer 1982; 50: 1434–1439.

    Article  PubMed  CAS  Google Scholar 

  57. Prasad KN, Sinha PK, Ramanujam M, Sakamoto A. Sodium ascorbate potentiates the growth inhibitory effect of certain agents on neuroblastoma cells in culture. Proc Natl Acad Sci USA 1979; 76: 829–832.

    Article  PubMed  CAS  Google Scholar 

  58. Nakano K, Fujimoto S, Tokita H. Antitumor activity of ascorbic acid in combination with antitumor agents against Lewis lung carcinoma.In Vivo 1988; 2: 247–252.

    PubMed  CAS  Google Scholar 

  59. Nakano K, Ohmori Y, Nishimura A, Fujita M, Honda I, Watanabe K, Sato H, Ishikawa I, Takahashi H. Adjuvant therapy for cancer using ascorbic acid. Proc Jpn Cancer Assoc 44th Annu Meet 1985; 481. (in Japanese)

  60. Nakano K, Ohmori Y, Fujita M, Honda I, Iwabuchi K, Tanaka N, Ueno T, Tokita H. High dose ascorbic acid therapy for patients with recurrence of the advanced cancer—Autopsy cases—. Proc Jpn Cancer Assoc 42nd Annu Meet 1983; 443. (in Japanese)

Download references

Author information

Authors and Affiliations

  1. The Division of Gastroenterology, Chiba Cancer Center Research Institute, Chiba, Japan

    Kikuo Nakano MD & Ichiro Honda

  2. Associate Director of Chiba Cancer Center Hospital, Chiba Cancer Center Research Institute, Chiba, Japan

    Hisashi Majima

  3. Division of Chemotherapy, Chiba Cancer Center Research Institute, Chiba, Japan

    Shuichi Fujimoto

Authors
  1. Kikuo Nakano MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ichiro Honda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hisashi Majima
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shuichi Fujimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nakano, K., Honda, I., Majima, H. et al. A case of calcifying carcinoma of the stomach with long-term postoperative survival. The Japanese Journal of Surgery 21, 335–340 (1991). https://doi.org/10.1007/BF02470956

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02470956

Key Words

Search

Navigation