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The Japanese journal of surgery

, Volume 21, Issue 3, pp 292–296 | Cite as

Lithium carbonate in the preoperative preparation of Graves' disease

  • Tsukasa Tsunoda
  • Nobuo Mochinaga
  • Toshifumi Eto
  • Minoru Yamaguchi
  • Ryoichi Tsuchiya
  • Motomori Izumi
Original Articles
  • 41 Downloads

Abstract

Lithium carbonate was given in the preoperative preparation of 12 patients with Graves' disease, the reasons for its use being side effects of thionamide in 9 patients, insufficient control by thionamide in 1 and psychic symptoms in 2. Lithium carbonate was often used in combination with other drugs, namely; thionamide in 4 patients, beta-adrenergic blockades in 5, reserpine in 5 and glucocorticoid in 1. This preoperative control significantly decreased the mean serum T2 and T4 levels from 656±55 ng/dl to 180±16 ng/dl and from 25.9±2.1 μg/dl to 9.7±1.5 μg/dl, respectively. The only adverse effect of lithium carbonate was pollakisuria observed in one patient. All patients underwent subtotal thyroidectomy uneventfully. It is concluded that the administration of lithium carbonate alone or in combination with other durgs is an effective method of preoperatively controlling hyperthyroidism when conventional antithyroid drugs show adverse effects.

Key Words

lithium carbonate Graves' disease preoperative preparation 

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Copyright information

© The Japan Surgical Society 1991

Authors and Affiliations

  • Tsukasa Tsunoda
    • 1
  • Nobuo Mochinaga
    • 1
  • Toshifumi Eto
    • 1
  • Minoru Yamaguchi
    • 1
  • Ryoichi Tsuchiya
    • 1
  • Motomori Izumi
    • 2
  1. 1.The Second Department of SurgeryNagasaki University School of MedicineNagasakiJapan
  2. 2.the First Department of Internal MedicineNagasaki University School of MedicineNagasakiJapan

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