Abstract
The relationship of tissue carcinoembryonic antigen (CEA) to clinicopathological factors and prognosis was investigated in 168 patients with invasive ductal carcinoma of the breast. Tissue CEA was determined by radioimmunoassay and a level of 5.1 ng/ml or more considered to be positive. Tissue CEA was positive in 31.5 per cent of the patients overall and, of the clinicopathological factors, tumor size and the presence or absence of lymph node involvement were not found to be correlated with tissue CEA. However, the tissue CEA positivity rate was significantly higher in patients who had four or more metastatic lymph nodes (p<0.01). Tissue CEA-positive patients showed earlier recurrence than CEA-negative patients (p<0.01) and had a poorer outcome (p<0.05). Thus, tissue CEA is considered useful as a prognostic index for primary breast cancer patients.
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Haga, S., Watanabe, O., Shimizu, T. et al. The clinical value of tissue carcinoembryonic antigen in breast cancer. The Japanese Journal of Surgery 21, 278–283 (1991). https://doi.org/10.1007/BF02470947
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DOI: https://doi.org/10.1007/BF02470947